Chronic myeloid leukemia (CML) is caused by the BCR-ABL hybrid gene. The molecular mechanisms leading from chronic phase (CP) to blast crisis (BC) are not understood. However, both the presence and the levels of BCR-ABL seem to be important for CML progression. BCR-ABL is under the transcriptional control of BCR promoter. Here we focused on the gene expression control of BCR and BCR-ABL upon myeloid differentiation in healthy donors (HDs), CP and BC patients. As previously reported, BCR-ABL is downregulated during myeloid maturation in CP patients. A similar pattern was detected for BCR (but not for ABL) in CP-CML and in HD, thus suggesting that the two genes may be under a similar transcriptional control. In BC this mechanism is similarly impaired for both BCR-ABL and BCR. These data indicate the presence of an 'in trans' deregulated transcription of both BCR and BCR-ABL promoters, associated with CML progression.
Marega, M., Piazza, R.G., Pirola, A., Redaelli, S., Mogavero, A., Iacobucci, I., et al. (2010). BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase/blast crisis CML patients. LEUKEMIA, 24(8), 1445-1449 [10.1038/leu.2010.101].
Citazione: | Marega, M., Piazza, R.G., Pirola, A., Redaelli, S., Mogavero, A., Iacobucci, I., et al. (2010). BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase/blast crisis CML patients. LEUKEMIA, 24(8), 1445-1449 [10.1038/leu.2010.101]. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Titolo: | BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase/blast crisis CML patients | |
Autori: | Marega, M; Piazza, RG; Pirola, A; Redaelli, S; Mogavero, A; Iacobucci, I; Meneghetti, I; Parma, M; Pogliani, EM; Gambacorti-Passerini, C | |
Autori: | ||
Data di pubblicazione: | 2010 | |
Lingua: | English | |
Rivista: | LEUKEMIA | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1038/leu.2010.101 | |
Appare nelle tipologie: | 01 - Articolo su rivista |