We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed
Occhipinti, E., Verderio, P., Natalello, A., Galbiati, E., Colombo, M., Mazzucchelli, S., et al. (2011). Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles. NANOSCALE, 3(2), 387-390 [10.1039/C0NR00436G].
Investigating the structural biofunctionality of antibodies conjugated to magnetic nanoparticles
NATALELLO, ANTONINO;COLOMBO, MIRIAM;TORTORA, PAOLO;DOGLIA, SILVIA MARIA;PROSPERI, DAVIDE
2011
Abstract
We present the synthesis of trastuzumab-functionalized pegylated iron oxide nanoparticles and provide an FTIR-based approach to gain a direct evidence of the actual conservation of the native structure of conjugated antibody. Their target-selectivity to specific cancer cell receptors has been also assessed
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