Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood-brain barrier (BBB) included, to reach their target. It is known that nanoparticles gather molecules on their surface upon contact with biological fluids, forming the "protein corona", which can affect their fate and therapeutic/diagnostic performance, yet no information on the corona's evolution across the barrier has been gathered so far. Using a cellular model of the BBB and gold nanoparticles, we show that the composition of the corona undergoes dramatic quantitative and qualitative molecular modifications during passage from the "blood" to the "brain" side, while it is stable once beyond the BBB. Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ.

Cox, A., Andreozzi, P., Dal Magro, R., Fiordaliso, F., Corbelli, A., Talamini, L., et al. (2018). Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier. ACS NANO, 12(7), 7292-7300 [10.1021/acsnano.8b03500].

Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier

COX, ALYSIA SARAH-MARIE
;
Dal Magro, Roberta;Chinello, Clizia;Raimondo, Francesca;Magni, Fulvio;Tringali, Maria;Masserini, Massimo;Re, Francesca
2018

Abstract

Engineered nanoparticles offer the chance to improve drug transport and delivery through biological barriers, exploiting the possibility to leave the blood circulation and traverse the endothelial vascular bed, blood-brain barrier (BBB) included, to reach their target. It is known that nanoparticles gather molecules on their surface upon contact with biological fluids, forming the "protein corona", which can affect their fate and therapeutic/diagnostic performance, yet no information on the corona's evolution across the barrier has been gathered so far. Using a cellular model of the BBB and gold nanoparticles, we show that the composition of the corona undergoes dramatic quantitative and qualitative molecular modifications during passage from the "blood" to the "brain" side, while it is stable once beyond the BBB. Thus, we demonstrate that the nanoparticle corona dynamically and drastically evolves upon crossing the BBB and that its initial composition is not predictive of nanoparticle fate and performance once beyond the barrier at the target organ.
Articolo in rivista - Articolo scientifico
biological barriers; blood-brain barrier; brain; nanoparticles; protein corona;
biological barriers; blood-brain barrier; brain; nanoparticles; protein corona; Materials Science (all); Engineering (all); Physics and Astronomy (all)
English
2018
12
7
7292
7300
reserved
Cox, A., Andreozzi, P., Dal Magro, R., Fiordaliso, F., Corbelli, A., Talamini, L., et al. (2018). Evolution of Nanoparticle Protein Corona across the Blood-Brain Barrier. ACS NANO, 12(7), 7292-7300 [10.1021/acsnano.8b03500].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/205461
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