IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishRATIONALE: During acute lung injury, mechanical ventilation can aggravate inflammation by promoting alveolar distension and cyclic recruitment-derecruitment. As an estimate of the intensity of inflammation, metabolic activity can be measured by positron emission tomography imaging of [(18)F]fluoro-2-deoxy-D-glucose. OBJECTIVE: To assess the relationship between gas volume changes induced by tidal ventilation and pulmonary metabolic activity in patients with acute lung injury. METHODS: In thirteen mechanically ventilated patients with acute lung injury and relatively high PEEP, we performed a positron emission tomography scan of the chest and three computed tomography scans: at mean airway pressure, end-expiration and end-inspiration. Metabolic activity was measured from the [(18)F]fluoro-2-deoxy-D-glucose uptake rate. The computed tomography scans were used to classify lung regions as derecruited throughout the respiratory cycle, undergoing recruitment-derecruitment, and normally aerated. MEASUREMENTS AND MAIN RESULTS: Metabolic activity of normally aerated lung was positively correlated both with plateau pressure, showing a pronounced increase above 26-27 cmH2O, and with regional tidal volume normalized by end-expiratory lung gas volume. This relationship did not appear to be caused by a higher underlying parenchymal metabolic activity in patients with higher plateau pressure. Regions undergoing cyclic recruitment-derecruitment did not have higher metabolic activity than those collapsed throughout the respiratory cycle. CONCLUSIONS: In patients with acute lung injury managed with relatively high end-expiratory pressure, metabolic activity of aerated regions was associated with both plateau pressure and regional tidal volume normalized by end-expiratory lung gas volume, while no association was found between cyclic recruitment-derecruitment and increased metabolic activity.
Bellani, G., Guerra, L., Musch, G., Zanella, A., Patroniti, N.A., Mauri, T., et al. (2011). Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(9), 1193-1199 [10.1164/rccm.201008-1318OC].
| Citazione: | Bellani, G., Guerra, L., Musch, G., Zanella, A., Patroniti, N.A., Mauri, T., et al. (2011). Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(9), 1193-1199 [10.1164/rccm.201008-1318OC]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | Lung Regional Metabolic Activity and Gas Volume Changes Induced by Tidal Ventilation in Patients with Acute Lung Injury | |
| Autori: | Bellani, G; Guerra, L; Musch, G; Zanella, A; Patroniti, NA; Mauri, T; Messa, MC; Pesenti, A | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Lingua: | English | |
| Rivista: | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1164/rccm.201008-1318OC | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
Copyright © 2021