Sudden cardiac death (SCD) is the leading cause of death in the age group 20–65 years, in the western world, with an enormous social and economic impact. The majority of the cases of ventricular fibrillation (VF) occur in patients without a preexisting structural heart disease and represent the first manifestation of coronary artery disease. In most of these cases, VF occurs in the early phase of myocardial infarction (MI) and it is then called primary VF. Although several factors have been associated in various studies with primary VF a recent metaanalysis found no evidence for risk factors other than ST elevation and time from onset of symptoms. In the past several years, few studies have found that a family history of sudden cardiac death (SCD) is a risk factor for primary VF suggesting that this dramatic event may be favored by the genetic background. To explore this possibility we designed the ongoing PREDESTINATION Study, enrolling subjects under 75 years of age with a first MI complicated by primary VF and a control group of subjects with a first uncomplicated MI. Data so far available confirm the association between a family history of SCD and primary VF and suggest that hypokalemia and prolonged QT interval may favor its occurrence. The genetic analysis has already provided some interesting suggestions that will need to be confirmed by the continuation of the enrolment and joint analysis with data deriving from similar patient populations.

De Ferrari, G., De Regibus, V., Gionti, V., Civardi, D., Insolia, R., Pedrazzini, M., et al. (2013). PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic basis. In New diagnostic, therapeutic and organizational strategies for a cute coronary syndromes patients (pp. 85-96). Springer-Verlag Italia srl [10.1007/978-88-470-5379-3_6].

PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic basis

Crotti L;
2013

Abstract

Sudden cardiac death (SCD) is the leading cause of death in the age group 20–65 years, in the western world, with an enormous social and economic impact. The majority of the cases of ventricular fibrillation (VF) occur in patients without a preexisting structural heart disease and represent the first manifestation of coronary artery disease. In most of these cases, VF occurs in the early phase of myocardial infarction (MI) and it is then called primary VF. Although several factors have been associated in various studies with primary VF a recent metaanalysis found no evidence for risk factors other than ST elevation and time from onset of symptoms. In the past several years, few studies have found that a family history of sudden cardiac death (SCD) is a risk factor for primary VF suggesting that this dramatic event may be favored by the genetic background. To explore this possibility we designed the ongoing PREDESTINATION Study, enrolling subjects under 75 years of age with a first MI complicated by primary VF and a control group of subjects with a first uncomplicated MI. Data so far available confirm the association between a family history of SCD and primary VF and suggest that hypokalemia and prolonged QT interval may favor its occurrence. The genetic analysis has already provided some interesting suggestions that will need to be confirmed by the continuation of the enrolment and joint analysis with data deriving from similar patient populations.
Capitolo o saggio
Acute Coronary Syndromes; Public Health Management; ventricular fibrillation; myocardial infarction; sudden death
English
New diagnostic, therapeutic and organizational strategies for a cute coronary syndromes patients
2013
9788847053786
Springer-Verlag Italia srl
85
96
De Ferrari, G., De Regibus, V., Gionti, V., Civardi, D., Insolia, R., Pedrazzini, M., et al. (2013). PREDESTINATION: PRimary vEntricular fibrillation and suDden dEath during a firST myocardIal iNfArcTION: Genetic basis. In New diagnostic, therapeutic and organizational strategies for a cute coronary syndromes patients (pp. 85-96). Springer-Verlag Italia srl [10.1007/978-88-470-5379-3_6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/189562
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