Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium. This strategy increased nanoparticle translocation into brain parenchyma, and improved brain nanoparticle accumulation 3-fold compared to undecorated particles (119.8 vs 40.5 picomoles). Apolipoprotein decorated nanoparticles have high clinical translational potential and may improve the development of nanotechnology-based medicine for a variety of neurological diseases.

Dal Magro, R., Albertini, B., Beretta, S., Rigolio, R., Donzelli, E., Chiorazzi, A., et al. (2018). Artificial apolipoprotein corona enables nanoparticle brain targeting. NANOMEDICINE, 14(2), 429-438 [10.1016/j.nano.2017.11.008].

Artificial apolipoprotein corona enables nanoparticle brain targeting

Dal Magro, R;Rigolio, R;Donzelli, E;Chiorazzi, A;Sancini, G.
Ultimo
2018

Abstract

Many potential therapeutic compounds for brain diseases fail to reach their molecular targets due to the impermeability of the blood-brain barrier, limiting their clinical development. Nanotechnology-based approaches might improve compounds pharmacokinetics by enhancing binding to the cerebrovascular endothelium and translocation into the brain. Adsorption of apolipoprotein E4 onto polysorbate 80-stabilized nanoparticles to produce a protein corona allows the specific targeting of cerebrovascular endothelium. This strategy increased nanoparticle translocation into brain parenchyma, and improved brain nanoparticle accumulation 3-fold compared to undecorated particles (119.8 vs 40.5 picomoles). Apolipoprotein decorated nanoparticles have high clinical translational potential and may improve the development of nanotechnology-based medicine for a variety of neurological diseases.
Articolo in rivista - Articolo scientifico
Apolipoprotein E4; Blood brain barrier; Brain targeting; Lipid nanoparticles; Protein corona;
English
2018
429
438
10
Dal Magro, R., Albertini, B., Beretta, S., Rigolio, R., Donzelli, E., Chiorazzi, A., et al. (2018). Artificial apolipoprotein corona enables nanoparticle brain targeting. NANOMEDICINE, 14(2), 429-438 [10.1016/j.nano.2017.11.008].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/175761
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