Introduction: Pharmacological inhibition of dipeptidyl-peptidase-4 may represent a promising therapeutic approach for glucose control and vascular protection. No information is available on the effects of saxagliptin (S) on aortic pulse wave velocity, carotid intima-media thickness and flow-mediated dilation (FMD, brachial artery) in diabetes. Aim: We investigated the long-term effects of S, as add-on therapy to metformin, on the above mentioned variables. Methods: In 16 patients with decompensated diabetes aortic pulse wave velocity, carotid intima-media thickness and FMD, office and 24-h ambulatory blood pressure, anthropometric, biochemical and metabolic parameters were measured at baseline and after 6 and 12 months of treatment. A group of 16 compensated diabetics served as controls. Results: The two groups showed superimposable values of the different parameters, with the exception of glycated hemoglobin, blood glucose significantly (P < 0.05) greater in the S-treated patients. In the S-group glucose metabolism and FMD significantly improved during the follow-up (from 169.3 ± 8 to 157.1 ± 9 mg/dl, P < 0.05, from 7.9 ± 0.1 to 6.9 ± 0.2%, P < 0.001 and from 3.6 ± 0.3 to 7.4 ± 0.8%, respectively P < 0.05). No significant difference was detected in the other parameters, including blood pressure. Conclusions: Thus treatment with S added-on to metformin results in beneficial effects on endothelial function, related at least in part to the concomitant improvement in glucose metabolism. This may represent a first step in the chain of events leading to a reduction in the progression of the vascular atherogenic process.

Dell'Oro, R., Maloberti, A., Nicoli, F., Villa, P., Gamba, P., Bombelli, M., et al. (2017). Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 24(4), 393-400 [10.1007/s40292-017-0215-2].

Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients

Dell'Oro, R;Maloberti, A;Nicoli, F;Villa, P;Bombelli, M;Mancia, G;Grassi, G
2017

Abstract

Introduction: Pharmacological inhibition of dipeptidyl-peptidase-4 may represent a promising therapeutic approach for glucose control and vascular protection. No information is available on the effects of saxagliptin (S) on aortic pulse wave velocity, carotid intima-media thickness and flow-mediated dilation (FMD, brachial artery) in diabetes. Aim: We investigated the long-term effects of S, as add-on therapy to metformin, on the above mentioned variables. Methods: In 16 patients with decompensated diabetes aortic pulse wave velocity, carotid intima-media thickness and FMD, office and 24-h ambulatory blood pressure, anthropometric, biochemical and metabolic parameters were measured at baseline and after 6 and 12 months of treatment. A group of 16 compensated diabetics served as controls. Results: The two groups showed superimposable values of the different parameters, with the exception of glycated hemoglobin, blood glucose significantly (P < 0.05) greater in the S-treated patients. In the S-group glucose metabolism and FMD significantly improved during the follow-up (from 169.3 ± 8 to 157.1 ± 9 mg/dl, P < 0.05, from 7.9 ± 0.1 to 6.9 ± 0.2%, P < 0.001 and from 3.6 ± 0.3 to 7.4 ± 0.8%, respectively P < 0.05). No significant difference was detected in the other parameters, including blood pressure. Conclusions: Thus treatment with S added-on to metformin results in beneficial effects on endothelial function, related at least in part to the concomitant improvement in glucose metabolism. This may represent a first step in the chain of events leading to a reduction in the progression of the vascular atherogenic process.
Articolo in rivista - Articolo scientifico
Arterial stiffness; Endothelial function; Inhibitors of dipeptidyl-peptidase-4; Saxagliptin; Shear stress; Ultrasonography;
Arterial stiffness; Endothelial function; Inhibitors of dipeptidyl-peptidase-4; Saxagliptin; Shear stress; Ultrasonography
English
393
400
8
Dell'Oro, R., Maloberti, A., Nicoli, F., Villa, P., Gamba, P., Bombelli, M., et al. (2017). Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients. HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION, 24(4), 393-400 [10.1007/s40292-017-0215-2].
Dell'Oro, R; Maloberti, A; Nicoli, F; Villa, P; Gamba, P; Bombelli, M; Mancia, G; Grassi, G
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/175716
Citazioni
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
Social impact