Renal denervation has been shown to reduce blood pressure in patients with uncontrolled hypertension, but less is known about its impact on quality of life. This analysis evaluated 12-month blood pressure and quality of life outcomes in 934 patients from the Global SYMPLICITY Registry who completed the EuroQoL five-dimensions three-level questionnaire (EQ-5D-3L). At baseline, 32% of patients reported anxiety/depression and 48% reported pain/discomfort. At 12 months (n=496), office and 24-hour ambulatory systolic blood pressure were reduced by 13.9±26.6 and 7.7±19.3 mm Hg, respectively, and 8% (P<.001) more patients reported no problems in anxiety/depression. Furthermore, numerically more patients reported no problems in pain/discomfort (4%, P=.08). Perceived health-related quality of life (visual analog scale) improved from baseline to 12 months (68±18 vs 73±17, P<.001), and the improvement was largest among patients with severe anxiety/depression at baseline (50±24 vs 64±22, P=.005 [n=32]). In this analysis, renal denervation was associated with a significant improvement in health-related quality of life, particularly anxiety/depression.
Kindermann, I., Wedegärtner, S., Mahfoud, F., Weil, J., Brilakis, N., Ukena, J., et al. (2017). Improvement in health-related quality of life after renal sympathetic denervation in real-world hypertensive patients: 12-month outcomes in the Global SYMPLICITY Registry. THE JOURNAL OF CLINICAL HYPERTENSION, 19(9), 833-839.
Citazione: | Kindermann, I., Wedegärtner, S., Mahfoud, F., Weil, J., Brilakis, N., Ukena, J., et al. (2017). Improvement in health-related quality of life after renal sympathetic denervation in real-world hypertensive patients: 12-month outcomes in the Global SYMPLICITY Registry. THE JOURNAL OF CLINICAL HYPERTENSION, 19(9), 833-839. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Presenza di un coautore afferente ad Istituzioni straniere: | Si |
Titolo: | Improvement in health-related quality of life after renal sympathetic denervation in real-world hypertensive patients: 12-month outcomes in the Global SYMPLICITY Registry |
Autori: | Kindermann, I; Wedegärtner, S; Mahfoud, F; Weil, J; Brilakis, N; Ukena, J; Ewen, S; Linz, D; Fahy, M; Mancia, G; Böhm, M |
Autori: | MANCIA, GIUSEPPE (Penultimo) |
Data di pubblicazione: | 2017 |
Lingua: | English |
Rivista: | THE JOURNAL OF CLINICAL HYPERTENSION |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/jch.13007 |
Appare nelle tipologie: | 01 - Articolo su rivista |