IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishAims: The use of β-blockers represents a milestone in the treatment of heart failure with reduced ejection fraction (HFrEF). Few studies have compared β-blockers in HFrEF, and there is little data on the effects of different doses. The present study aimed to investigate in a large database of HFrEF patients (MECKI score database) the association of β-blocker treatment with a composite outcome of cardiovascular death, urgent heart transplantation or left ventricular assist device implantation, addressing the role of β-selectivity and dosage regimens. Methods and results: In 5242 HFrEF patients, we investigated the role of: (i) β-blocker treatment vs. non-β-blocker treatment, (ii) β1-/β2-receptor-blockers vs. β1-selective blockers, and (iii) daily β-blocker dose. Patients were followed for 3.58 years, and 1101 events (18.3%) were observed; 4435 patients (86.8%) were on β-blockers, while 807 (13.2%) were not. At 5 years, β-blocker-patients showed a better outcome than non-β-blocker-subjects [hazard ratio (HR) 0.48, P < 0.0001], while also considering potential confounders. A comparable prognosis was observed at 5 years in the β1-/β2-receptor-blocker (n = 2219) vs. β1-selective group (n = 2216) (HR 0.95, P = ns). A better prognosis was observed in high-dose (>2 5 mg carvedilol equivalent daily dose, n = 1005) patients than in both medium dose (12.5â25 mg, n = 1431) and low dose (<12.5 mg, n = 1960) (HR 1.97, P < 0.001; HR 1.95, P = 0.001, respectively), with no differences between the last two groups (HR 0.84, P = ns). Conclusion: In a large population of chronic HFrEF patients, β-blockers were associated with a more favourable prognosis without any difference between β1- and β2-receptor-blockers vs. β1-selective blockers. A better outcome was observed in subjects receiving a high daily dose.
Paolillo, S., Mapelli, M., Bonomi, A., Corrã , U., Piepoli, M., Veglia, F., et al. (2017). Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database. EUROPEAN JOURNAL OF HEART FAILURE, 19(7), 904-914 [10.1002/ejhf.775].
| Citazione: | Paolillo, S., Mapelli, M., Bonomi, A., Corrã , U., Piepoli, M., Veglia, F., et al. (2017). Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database. EUROPEAN JOURNAL OF HEART FAILURE, 19(7), 904-914 [10.1002/ejhf.775]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Prognostic role of β-blocker selectivity and dosage regimens in heart failure patients. Insights from the MECKI score database | |
| Autori: | Paolillo, S; Mapelli, M; Bonomi, A; Corrã , U; Piepoli, M; Veglia, F; Salvioni, E; Gentile, P; Lagioia, R; Metra, M; Limongelli, G; Sinagra, G; Cattadori, G; Scardovi, A; Carubelli, V; Scrutino, D; Badagliacca, R; Raimondo, R; Emdin, M; Magrã¬, D; Correale, M; Parati, G; Caravita, S; Spadafora, E; Re, F; Cicoira, M; Frigerio, M; Bussotti, M; Minã , C; Oliva, F; Battaia, E; Belardinelli, R; Mezzani, A; Pastormerlo, L; Di Lenarda, A; Passino, C; Sciomer, S; Iorio, A; Zambon, E; Guazzi, M; Pacileo, G; Ricci, R; Contini, M; Apostolo, A; Palermo, P; Clemenza, F; Marchese, G; Binno, S; Lombardi, C; Passantino, A; Perrone Filardi, P; Agostoni, P | |
| Autori: | ||
| Data di pubblicazione: | 2017 | |
| Lingua: | English | |
| Rivista: | EUROPEAN JOURNAL OF HEART FAILURE | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/ejhf.775 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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