Purpose: In tumour, the imbalance between oxygen supply and demand leads to hypoxia, which represents a negative prognostic factor associated with aggressive tumour phenotype and therapy resistance. This review provides an overview of the use of positron emitter-labelled radiopharmaceutical used to image hypoxia in preclinical models of cancer. Methods: A critical and comprehensive PubMed search was performed identifying articles related to PET imaging for hypoxia assessment in preclinical setting from January 2007 up to January 2017. Results: We have considered and described a total of 54 original articles, exploring tumour-associated hypoxia in preclinical models. Results underlined the potential application together with the advantages and pitfalls of the use of PET in preclinical research. Multi-target imaging allowed to better define the relationship between hypoxia and other biological hallmarks of tumour; imaging of hypoxia was proved as a useful tool for lesions stratification and response prediction to radiotherapy; however, cutoff indexes were identified in few studies. Hypoxia PET showed remarkable tracer delivery limitations in the study of vascular disrupting agents but suggested the potential use of PET as a marker of response or resistance to anti-angiogenics. Finally, the effect of anaesthesia on tracer kinetics and tumour oxygenation as well as perfusion dependency in tracer uptake should be carefully evaluated to avoid artefactual results. Conclusions: Preclinical studies highlight the advantages and the limitations of the available hypoxia-radiotracers and their potential usefulness for the evaluation of treatments outcome and radiotherapy planning
Raccagni, I., Valtorta, S., Moresco, R., & Belloli, S. (2017). Tumour hypoxia: lessons learnt from preclinical imaging. CLINICAL AND TRANSLATIONAL IMAGING, 5(5), 407-425 [10.1007/s40336-017-0248-5].
Citazione: | Raccagni, I., Valtorta, S., Moresco, R., & Belloli, S. (2017). Tumour hypoxia: lessons learnt from preclinical imaging. CLINICAL AND TRANSLATIONAL IMAGING, 5(5), 407-425 [10.1007/s40336-017-0248-5]. | |
Tipo: | Articolo in rivista - Review Essay | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Tumour hypoxia: lessons learnt from preclinical imaging | |
Autori: | Raccagni, I; Valtorta, S; Moresco, R; Belloli, S | |
Autori: | RACCAGNI, ISABELLA (Primo) VALTORTA, SILVIA (Secondo) MORESCO, ROSA MARIA (Penultimo) BELLOLI, SARA (Ultimo) | |
Data di pubblicazione: | 2017 | |
Lingua: | English | |
Rivista: | CLINICAL AND TRANSLATIONAL IMAGING | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s40336-017-0248-5 | |
Appare nelle tipologie: | 01 - Articolo su rivista |