IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishPurpose: In tumour, the imbalance between oxygen supply and demand leads to hypoxia, which represents a negative prognostic factor associated with aggressive tumour phenotype and therapy resistance. This review provides an overview of the use of positron emitter-labelled radiopharmaceutical used to image hypoxia in preclinical models of cancer. Methods: A critical and comprehensive PubMed search was performed identifying articles related to PET imaging for hypoxia assessment in preclinical setting from January 2007 up to January 2017. Results: We have considered and described a total of 54 original articles, exploring tumour-associated hypoxia in preclinical models. Results underlined the potential application together with the advantages and pitfalls of the use of PET in preclinical research. Multi-target imaging allowed to better define the relationship between hypoxia and other biological hallmarks of tumour; imaging of hypoxia was proved as a useful tool for lesions stratification and response prediction to radiotherapy; however, cutoff indexes were identified in few studies. Hypoxia PET showed remarkable tracer delivery limitations in the study of vascular disrupting agents but suggested the potential use of PET as a marker of response or resistance to anti-angiogenics. Finally, the effect of anaesthesia on tracer kinetics and tumour oxygenation as well as perfusion dependency in tracer uptake should be carefully evaluated to avoid artefactual results. Conclusions: Preclinical studies highlight the advantages and the limitations of the available hypoxia-radiotracers and their potential usefulness for the evaluation of treatments outcome and radiotherapy planning
Raccagni, I., Valtorta, S., Moresco, R., & Belloli, S. (2017). Tumour hypoxia: lessons learnt from preclinical imaging. CLINICAL AND TRANSLATIONAL IMAGING, 5(5), 407-425 [10.1007/s40336-017-0248-5].
| Citazione: | Raccagni, I., Valtorta, S., Moresco, R., & Belloli, S. (2017). Tumour hypoxia: lessons learnt from preclinical imaging. CLINICAL AND TRANSLATIONAL IMAGING, 5(5), 407-425 [10.1007/s40336-017-0248-5]. | |
| Tipo: | Articolo in rivista - Review Essay | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Tumour hypoxia: lessons learnt from preclinical imaging | |
| Autori: | Raccagni, I; Valtorta, S; Moresco, R; Belloli, S | |
| Autori: | RACCAGNI, ISABELLA (Primo) VALTORTA, SILVIA (Secondo) MORESCO, ROSA MARIA (Penultimo) BELLOLI, SARA (Ultimo) | |
| Data di pubblicazione: | 2017 | |
| Lingua: | English | |
| Rivista: | CLINICAL AND TRANSLATIONAL IMAGING | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s40336-017-0248-5 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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