IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishThe brain is always confronted with the dilemma of the protection from noxious substances from the blood and the delivery of vital metabolites. Endothelial cells, forming together with other cells the blood-brain barrier (BBB), are known as the “gatekeepers” of this trafficking. It is known that many common drugs cannot cross the BBB in appreciable concentrations, thus decreasing the rate of possible available treatments for many central nervous system (CNS) diseases. In the last decades, nanomedicine has increase its role in developing strategies to deliver drugs to the CNS. In our previous studies we administrated liposomes functionalized with phosphatidic acid and an ApoE-derived peptide as a potential treatment for Alzheimer’s disease (AD): their administration reduced brain beta-amyloid burden and ameliorated impaired memory in AD mice. Furthermore, we evaluated the adaptability of warm microemulsion process for ligand surface modification of solid lipid nanoparticles with ApoE to target the BBB and we investigated how the different administration routes affect their brain bioavailability. The aim of this study is to evaluate the interaction of lipid based nanoparticles (NPs) at the neurovascular unit. In light of our previous results we here assess the NPs interaction with human cerebral microvascular cells (hCMEC/D3) as in vitro BBB model and mice brain neuronal slices by means of patch clamp recordings and simultaneously calcium imaging measurements to follow calcium dinamics transients. Our studies of the NPs impact to the main neurophysiological functions should encourage further applications of NPs based drug delivery strategies for future clinical treatments of CNS diseases
Forcaia, G., Dal Magro, R., Cesana, E., Albertini, B., Blasi, P., Re, F., et al. (2017). Nanoparticles at the neurovascular unit: in vitro and in vivo studies to assess the blood-brain barrier permeability and function. In ACTA PHYSIOLOGICA, Vol. 221, Issue S713, September 2017, pages 162-209 (pp.176-177).
| Citazione: | Forcaia, G., Dal Magro, R., Cesana, E., Albertini, B., Blasi, P., Re, F., et al. (2017). Nanoparticles at the neurovascular unit: in vitro and in vivo studies to assess the blood-brain barrier permeability and function. In ACTA PHYSIOLOGICA, Vol. 221, Issue S713, September 2017, pages 162-209 (pp.176-177). | |
| Tipo: | abstract + poster | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Nanoparticles at the neurovascular unit: in vitro and in vivo studies to assess the blood-brain barrier permeability and function | |
| Autori: | Forcaia, G; Dal Magro, R; Cesana, E; Albertini, B; Blasi, P; Re, F; Sancini, G | |
| Autori: | FORCAIA, GRETA (Primo) SANCINI, GIULIO ALFREDO (Ultimo) | |
| Data di pubblicazione: | 2017 | |
| Lingua: | English | |
| Nome del convegno: | FEPS 2017 - Meeting of the Federation of European Physiological Societies September 13-15 | |
| Rivista: | ACTA PHYSIOLOGICA | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/apha.12941 | |
| Appare nelle tipologie: | 02 - Intervento a convegno |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| FEPS_2017_C03-3_Forcaia_G.doc | Abstract Poster Session C03-3 | N/A | Administrator Richiedi una copia |
http://hdl.handle.net/10281/170205
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