IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishAspiration pneumonitis, a direct cause of acute lung injury, is associated to a severe deterioration of lung function due in part to endogenous surfactant system impairment. We evaluated the effects of selective exogenous surfactant administration in a murine model of acid-induced lung injury both at short and long term. Hydrochloric acid was instilled into the right bronchus of the mice (0.1 M, 1.5 ml/kg). Six hours from acid instillation, they received, in the injured lung, a 1 ml/kg bolus of porcine surfactant (Curosurf ®) 40 or 80 mg phospholipids/ml (Surf 40 or Surf 80), or saline (0.9% NaCl, vehicle) Functional, biochemical, histological and inflammatory results were obtained 24 h after injury. In the Surf 80 and vehicle group, lung mechanics and histology were assessed again after two weeks. Micro-Computed Tomography scans were performed at 24 h and two weeks. 24 h after injury in the Surf 80 group respiratory system compliance and oxygenation were significantly improved compared to the vehicle, while neutrophilic fraction in bronchoalveolar lavage was significantly lower. Surfactant-treated mice maintained a better compliance and a significantly reduced inflammatory infiltrate also two weeks after treatment compared to vehicle. Micro-Computed Tomography scan suggested a more pronounced reduction of injury in surfactant-treated animals two weeks after injury (p = 0.09). We showed a beneficial effect on lung function of a single bolus of exogenous surfactant in unilateral acid-induced lung injury up to two weeks after treatment. Our results may suggest a role of surfactant replacement in modulating spontaneous evolution of injury. © 2010 Elsevier Ltd.
Scanziani, M., Amigoni, M., Bellani, G., Zambelli, V., Masson, S., Radaelli, E., et al. (2011). The effect of a single bolus of exogenous surfactant on lung compliance persists until two weeks after treatment in a model of acid aspiration pneumonitis. PULMONARY PHARMACOLOGY & THERAPEUTICS, 24(1), 141-146 [10.1016/j.pupt.2010.07.004].
| Citazione: | Scanziani, M., Amigoni, M., Bellani, G., Zambelli, V., Masson, S., Radaelli, E., et al. (2011). The effect of a single bolus of exogenous surfactant on lung compliance persists until two weeks after treatment in a model of acid aspiration pneumonitis. PULMONARY PHARMACOLOGY & THERAPEUTICS, 24(1), 141-146 [10.1016/j.pupt.2010.07.004]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | The effect of a single bolus of exogenous surfactant on lung compliance persists until two weeks after treatment in a model of acid aspiration pneumonitis | |
| Autori: | Scanziani, M; Amigoni, M; Bellani, G; Zambelli, V; Masson, S; Radaelli, E; Pesenti, A; Latini, R | |
| Autori: | ||
| Data di pubblicazione: | 2011 | |
| Lingua: | English | |
| Rivista: | PULMONARY PHARMACOLOGY & THERAPEUTICS | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.pupt.2010.07.004 | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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