Nutritional factors play a pivotal role for healthy aging and longevity. This is related to the antioxidant properties of the molecules present in some foods. Due to the high content of polyphenols, Green Coffee Extract (GCE) is a powerful antioxidant. Nevertheless, little is known about its effect on aging. We demonstrated the benefic effects of GCE on stress resistance, fertility and adult mean lifespan using Caenorhabditis elegans as a model. The mean and maximum lifespan of worms treated with GCE increased significantly in a dose-dependent manner, and animals pre-treated were more resistant to oxidative stress. NMR and UPLC/ESI-HRMS analyses of GCE confirmed a significant content of chlorogenic acids, being 5-O-caffeoylquinic acid (5-CQA) the most abundant isomer. The major activity demonstrated by GCE in comparison to the pure 5-CQA on C. elegans phenotypes clearly demonstrated the importance of the employment of a natural extract to develop functional foods and supplements.

Amigoni, L., Stuknytė, M., Ciaramelli, C., Magoni, C., Bruni, I., De Noni, I., et al. (2017). Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans. JOURNAL OF FUNCTIONAL FOODS, 33, 297-306 [10.1016/j.jff.2017.03.056].

Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans

AMIGONI, LOREDANA
Primo
;
CIARAMELLI, CARLOTTA;MAGONI, CHIARA;BRUNI, ILARIA;AIROLDI, CRISTINA;REGONESI, MARIA ELENA;PALMIOLI, ALESSANDRO
Ultimo
2017

Abstract

Nutritional factors play a pivotal role for healthy aging and longevity. This is related to the antioxidant properties of the molecules present in some foods. Due to the high content of polyphenols, Green Coffee Extract (GCE) is a powerful antioxidant. Nevertheless, little is known about its effect on aging. We demonstrated the benefic effects of GCE on stress resistance, fertility and adult mean lifespan using Caenorhabditis elegans as a model. The mean and maximum lifespan of worms treated with GCE increased significantly in a dose-dependent manner, and animals pre-treated were more resistant to oxidative stress. NMR and UPLC/ESI-HRMS analyses of GCE confirmed a significant content of chlorogenic acids, being 5-O-caffeoylquinic acid (5-CQA) the most abundant isomer. The major activity demonstrated by GCE in comparison to the pure 5-CQA on C. elegans phenotypes clearly demonstrated the importance of the employment of a natural extract to develop functional foods and supplements.
Articolo in rivista - Articolo scientifico
Antioxidant activity; Caenorhabditis elegans; Chlorogenic acids; Green coffee extract; High resolution mass spectrometry; NMR spectroscopy;
Green coffee extract; Chlorogenic acids; Antioxidant activity; High resolution mass spectrometry; NMR spectroscopy; Caenorhabditis elegans
English
297
306
10
Amigoni, L., Stuknytė, M., Ciaramelli, C., Magoni, C., Bruni, I., De Noni, I., et al. (2017). Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans. JOURNAL OF FUNCTIONAL FOODS, 33, 297-306 [10.1016/j.jff.2017.03.056].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/150653
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