Anti-glomerular basement membrane (GBM) antibody disease is a rare pathological condition that mainly involves renal and/or pulmonary parenchyma. It is characterized by the presence of circulating anti-GBM antibodies accompanied by a linear deposition of immunoglobulins (Ig) detected through immunofluorescence (IF) technique and typical signs and symptoms of organ dysfunction, such as rapidly progressive glomerulonephritis (RPGN) and pulmonary hemorrhage (PH). However, recently atypical forms of anti-GBM disease have been described and the presence of overlapping diseases contributed to make its diagnosis challenging. In this review will be discussed the entire spectrum of renal anti-GBM related conditions, focusing the attention on the differences in terms of pathogenesis, diagnosis and therapy of these disparate entities.

L'Imperio, V., Ajello, E., Pieruzzi, F., Nebuloni, M., Tosoni, A., Ferrario, F., et al. (2017). Clinicopathological characteristics of typical and atypical anti-glomerular basement membrane nephritis. JN. JOURNAL OF NEPHROLOGY, 30(4), 503-509 [10.1007/s40620-017-0394-x].

Clinicopathological characteristics of typical and atypical anti-glomerular basement membrane nephritis

L'Imperio, V;Ajello, E;Pieruzzi, F;Pagni, F
2017

Abstract

Anti-glomerular basement membrane (GBM) antibody disease is a rare pathological condition that mainly involves renal and/or pulmonary parenchyma. It is characterized by the presence of circulating anti-GBM antibodies accompanied by a linear deposition of immunoglobulins (Ig) detected through immunofluorescence (IF) technique and typical signs and symptoms of organ dysfunction, such as rapidly progressive glomerulonephritis (RPGN) and pulmonary hemorrhage (PH). However, recently atypical forms of anti-GBM disease have been described and the presence of overlapping diseases contributed to make its diagnosis challenging. In this review will be discussed the entire spectrum of renal anti-GBM related conditions, focusing the attention on the differences in terms of pathogenesis, diagnosis and therapy of these disparate entities.
Articolo in rivista - Review Essay
Anti-GBM disease; Crescentic glomerulonephritis; Nephropathology; Rapidly progressive glomerulonephritis
English
503
509
7
L'Imperio, V., Ajello, E., Pieruzzi, F., Nebuloni, M., Tosoni, A., Ferrario, F., et al. (2017). Clinicopathological characteristics of typical and atypical anti-glomerular basement membrane nephritis. JN. JOURNAL OF NEPHROLOGY, 30(4), 503-509 [10.1007/s40620-017-0394-x].
L'Imperio, V; Ajello, E; Pieruzzi, F; Nebuloni, M; Tosoni, A; Ferrario, F; Pagni, F
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/149902
Citazioni
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 8
Social impact