Aim. The growth of gliomas depends on the balance of factors stimulating or inhibiting angiogenesis, tumor cell invasion and proliferation. The administration of endogenous inhibitors to experimental human gliomas in animal models resulted in a significant inhibition of tumor growth. It is becoming apparent that resistance can develop over time to many types of endogenous inhibitors and seems to be influenced by the tumor type and system of delivery. Methods. We recently isolated a potent endogenous inhibitor, called human PEX, from human glioma cells in culture. Human PEX is a potent inhibitor of angiogenesis, tumor and endothelial cell proliferation and migration. In this paper, we investigated the ability of human PEX to sustain inhibition of glioma growth for a prolonged period of time. We initially developed a recombinant form of the inhibitor and showed that this form had similar in vitro and in vivo activities to the natural one. Human PEX was then administered to nude mice intr...

Pluderi, M., Lucini, V., Caronzolo, D., Pannacci, M., Costa, F., Carrabba, G., et al. (2003). Long-term inhibition of glioma growth by systemic administration of human PEX. JOURNAL OF NEUROSURGICAL SCIENCES, 47(2), 69-78.

Long-term inhibition of glioma growth by systemic administration of human PEX

Carrabba, G;GIUSSANI, CARLO GIORGIO;
2003

Abstract

Aim. The growth of gliomas depends on the balance of factors stimulating or inhibiting angiogenesis, tumor cell invasion and proliferation. The administration of endogenous inhibitors to experimental human gliomas in animal models resulted in a significant inhibition of tumor growth. It is becoming apparent that resistance can develop over time to many types of endogenous inhibitors and seems to be influenced by the tumor type and system of delivery. Methods. We recently isolated a potent endogenous inhibitor, called human PEX, from human glioma cells in culture. Human PEX is a potent inhibitor of angiogenesis, tumor and endothelial cell proliferation and migration. In this paper, we investigated the ability of human PEX to sustain inhibition of glioma growth for a prolonged period of time. We initially developed a recombinant form of the inhibitor and showed that this form had similar in vitro and in vivo activities to the natural one. Human PEX was then administered to nude mice intr...
Articolo in rivista - Articolo scientifico
Angiogenesis inhibitors; Endogenous inhibitors; Glioma, therapy;
Angiogenesis Inhibitors; Animals; Apoptosis; Blotting, Western; Cell Division; Disease Models, Animal; Endothelial Cells; Glioma; Humans; Male; Matrix Metalloproteinase 2; Mice; Mice, Nude; Neoplasm Transplantation; Peptide Fragments; Polymerase Chain Reaction; Recombinant Proteins; Time Factors; Tumor Cells, Cultured
English
2003
47
2
69
78
reserved
Pluderi, M., Lucini, V., Caronzolo, D., Pannacci, M., Costa, F., Carrabba, G., et al. (2003). Long-term inhibition of glioma growth by systemic administration of human PEX. JOURNAL OF NEUROSURGICAL SCIENCES, 47(2), 69-78.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/148271
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