It has been well recognized that many key aspects of cell cycle regulation are encoded into the size distributions of growing budding yeast populations due to the tight coupling between cell growth and cell division present in this organism. Several attempts have been made to model the cell size distribution of growing yeast populations in order to obtain insight on the underlying control mechanisms, but most were based on the age structure of asymmetrically dividing populations. Here we propose a new framework that couples a morphologically-structured representation of the population with population balance theory to formulate a dynamic model for the size distribution of growing yeast populations. An advantage of the presented framework is that it allows derivation of simpler models that are directly identifiable from experiments. We show how such models can be derived from the general framework and demonstrate their utility in analyzing yeast population data. Finally, by employing a recently proposed numerical scheme, we proceed to integrate numerically the full distributed model to provide predictions of dynamics of the cell size structure of growing yeast populations.

Hatzis, C., Porro, D. (2006). Morphologically-Structured Models of Growing Budding Yeast Populations. JOURNAL OF BIOTECHNOLOGY, 124(2), 420-438 [10.1016/j.jbiotec.2006.01.011].

Morphologically-Structured Models of Growing Budding Yeast Populations

PORRO, DANILO
2006

Abstract

It has been well recognized that many key aspects of cell cycle regulation are encoded into the size distributions of growing budding yeast populations due to the tight coupling between cell growth and cell division present in this organism. Several attempts have been made to model the cell size distribution of growing yeast populations in order to obtain insight on the underlying control mechanisms, but most were based on the age structure of asymmetrically dividing populations. Here we propose a new framework that couples a morphologically-structured representation of the population with population balance theory to formulate a dynamic model for the size distribution of growing yeast populations. An advantage of the presented framework is that it allows derivation of simpler models that are directly identifiable from experiments. We show how such models can be derived from the general framework and demonstrate their utility in analyzing yeast population data. Finally, by employing a recently proposed numerical scheme, we proceed to integrate numerically the full distributed model to provide predictions of dynamics of the cell size structure of growing yeast populations.
Articolo in rivista - Articolo scientifico
Population balance; Size distribution; Size control; Structured model; Saccharomyces cerevisiae; Cell cycle control
English
2006
124
2
420
438
none
Hatzis, C., Porro, D. (2006). Morphologically-Structured Models of Growing Budding Yeast Populations. JOURNAL OF BIOTECHNOLOGY, 124(2), 420-438 [10.1016/j.jbiotec.2006.01.011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/14666
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