BACKGROUND: We previously described an index, defined as the ratio between the inspiratory muscle pressure (Pmus) and the electrical activity of the diaphragm (EAdi) (Pmus/EAdi index). In the present work, we describe the trend of Pmus/EAdi index over time, investigating whether it could be an indicator of muscular efficiency associated with risk factors for diaphragmatic injury and/or clinical outcomes. METHODS: This work is a retrospective analysis of subjects with measurements of Pmus/EAdi index obtained, on different days, during assisted ventilation. Effects of Pmus/EAdi index absolute value on clinical outcomes were investigated dividing subjects into those with Pmus/EAdi index higher or lower than the median. Effects of Pmus/EAdi index trend over time were analyzed, distinguishing between subjects with Pmus/EAdi index increasing or decreasing. RESULTS: Mean Pmus/EAdi index was 1.04 ± 0.67, and the median (interquartile range) was 1.00 (0.59 –1.34), without a systematic trend over the days. Demographic, ventilator, or outcome data did not significantly differ between subjects with Pmus/EAdi index higher or lower than the median. Similarly, we did not find relevant differences in subjects with Pmus/EAdi index increasing or decreasing over time. CONCLUSIONS: The Pmus/EAdi index value remained constant in each subject over time, although the inter-individual variability was high. Neither the Pmus/EAdi index nor its trends appeared to be associated with ventilatory variables or clinical outcome.

Bellani, G., Coppadoro, A., Pozzi, M., Bronco, A., Albiero, D., Eronia, N., et al. (2016). The ratio of inspiratory pressure over electrical activity of the diaphragm remains stable during icu stay and is not related to clinical outcome. RESPIRATORY CARE, 61(4), 495-501 [10.4187/respcare.04400].

The ratio of inspiratory pressure over electrical activity of the diaphragm remains stable during icu stay and is not related to clinical outcome

BELLANI, GIACOMO
Primo
;
COPPADORO, ANDREA
Secondo
;
POZZI, MATTEO;BRONCO, ALFIO;ALBIERO, DANIELA;ERONIA, NILDE;MERONI, VALERIA;GRASSELLI, GIACOMO
;
PESENTI, ANTONIO MARIA
Ultimo
2016

Abstract

BACKGROUND: We previously described an index, defined as the ratio between the inspiratory muscle pressure (Pmus) and the electrical activity of the diaphragm (EAdi) (Pmus/EAdi index). In the present work, we describe the trend of Pmus/EAdi index over time, investigating whether it could be an indicator of muscular efficiency associated with risk factors for diaphragmatic injury and/or clinical outcomes. METHODS: This work is a retrospective analysis of subjects with measurements of Pmus/EAdi index obtained, on different days, during assisted ventilation. Effects of Pmus/EAdi index absolute value on clinical outcomes were investigated dividing subjects into those with Pmus/EAdi index higher or lower than the median. Effects of Pmus/EAdi index trend over time were analyzed, distinguishing between subjects with Pmus/EAdi index increasing or decreasing. RESULTS: Mean Pmus/EAdi index was 1.04 ± 0.67, and the median (interquartile range) was 1.00 (0.59 –1.34), without a systematic trend over the days. Demographic, ventilator, or outcome data did not significantly differ between subjects with Pmus/EAdi index higher or lower than the median. Similarly, we did not find relevant differences in subjects with Pmus/EAdi index increasing or decreasing over time. CONCLUSIONS: The Pmus/EAdi index value remained constant in each subject over time, although the inter-individual variability was high. Neither the Pmus/EAdi index nor its trends appeared to be associated with ventilatory variables or clinical outcome.
Articolo in rivista - Articolo scientifico
Diaphragm; Electromyography; Muscle pressure; Neutrally adjusted ventilator assist; Pressure support; Weaning;
Diaphragm; Electromyography; Muscle pressure; Neutrally adjusted ventilator assist; Pressure support; Weaning; Aged; Diaphragm; Electromyography; Female; Humans; Length of Stay; Male; Maximal Respiratory Pressures; Middle Aged; Respiration, Artificial; Respiratory Muscles; Retrospective Studies; Treatment Outcome; Health Status Indicators; Intensive Care Units; Pulmonary and Respiratory Medicine; Critical Care and Intensive Care Medicine
English
495
501
7
Bellani, G., Coppadoro, A., Pozzi, M., Bronco, A., Albiero, D., Eronia, N., et al. (2016). The ratio of inspiratory pressure over electrical activity of the diaphragm remains stable during icu stay and is not related to clinical outcome. RESPIRATORY CARE, 61(4), 495-501 [10.4187/respcare.04400].
Bellani, G; Coppadoro, A; Pozzi, M; Bronco, A; Albiero, D; Eronia, N; Meroni, V; Grasselli, G; Pesenti, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/140021
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