Background: The objective of this study is to evaluate the safety of fertility-sparing surgery (FSS) for early-stage epithelial ovarian cancer (EOC). Methods: A retrospective analysis was performed to identify patients treated for early-stage EOC and to compare the clinical outcomes of patients treated with FSS and radical surgery (RS). Results: A total of 1031 patients were treated at two Institutions, 242 with FSS (group A) and 789 with RS (group B). Median duration of follow-up was 11.9 years. At univariate analyses, FSS was associated with decreased risk of relapse (P=0.002) and of tumour-related death (P=0.001). Multivariate analysis did not confirm the independent positive role of FSS neither on relapse-free interval (RFI) nor on cancer-specific survival (CSS). Tumour grade was associated with shorter RFI (P<0.001) and shorter CSS (P=0.001). The type of treatment did not influence CSS or RFI in any grade group. We also found a significant association between low-grade tumours and younger age. Conclusions: Fertility-sparing surgery is an adequate treatment for patients with stage I EOC. The clinical outcome of patients with G3 tumours, which is confirmed to be the most important prognostic factor, is not determined by the type of treatment received.

Fruscio, R., Ceppi, L., Corso, S., Galli, F., Dell'Anna, T., Dell'Orto, F., et al. (2016). Long-term results of fertility-sparing treatment compared with standard radical surgery for early-stage epithelial ovarian cancer. BRITISH JOURNAL OF CANCER, 115(6), 641-648 [10.1038/bjc.2016.254].

Long-term results of fertility-sparing treatment compared with standard radical surgery for early-stage epithelial ovarian cancer

FRUSCIO, ROBERT
Primo
;
CEPPI, LORENZO
Secondo
;
DELL' ANNA, TIZIANA;DELL'ORTO, FEDERICA;GIULIANI, DANIELA;MILANI, RODOLFO;COLOMBO, NICOLETTA
Penultimo
;
2016

Abstract

Background: The objective of this study is to evaluate the safety of fertility-sparing surgery (FSS) for early-stage epithelial ovarian cancer (EOC). Methods: A retrospective analysis was performed to identify patients treated for early-stage EOC and to compare the clinical outcomes of patients treated with FSS and radical surgery (RS). Results: A total of 1031 patients were treated at two Institutions, 242 with FSS (group A) and 789 with RS (group B). Median duration of follow-up was 11.9 years. At univariate analyses, FSS was associated with decreased risk of relapse (P=0.002) and of tumour-related death (P=0.001). Multivariate analysis did not confirm the independent positive role of FSS neither on relapse-free interval (RFI) nor on cancer-specific survival (CSS). Tumour grade was associated with shorter RFI (P<0.001) and shorter CSS (P=0.001). The type of treatment did not influence CSS or RFI in any grade group. We also found a significant association between low-grade tumours and younger age. Conclusions: Fertility-sparing surgery is an adequate treatment for patients with stage I EOC. The clinical outcome of patients with G3 tumours, which is confirmed to be the most important prognostic factor, is not determined by the type of treatment received.
Articolo in rivista - Articolo scientifico
fertility sparing surgery; ovarian cancer; survival;
English
641
648
8
Fruscio, R., Ceppi, L., Corso, S., Galli, F., Dell'Anna, T., Dell'Orto, F., et al. (2016). Long-term results of fertility-sparing treatment compared with standard radical surgery for early-stage epithelial ovarian cancer. BRITISH JOURNAL OF CANCER, 115(6), 641-648 [10.1038/bjc.2016.254].
Fruscio, R; Ceppi, L; Corso, S; Galli, F; DELL' ANNA, T; Dell'Orto, F; Giuliani, D; Garbi, A; Chiari, S; Mangioni, C; Milani, R; Floriani, I; Colombo, N; Bonazzi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/131038
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