Schistosomes are helminth parasites that display a dual impact on the immune system of their hosts. Although the larval stage, also known as schistosomulum, appears to subvert the host defenses, the egg stage induces strong inflammatory reactions. Given the pivotal role of dendritic cells (DC) in initiating and regulating immune responses, we compared the distinct transcriptional programs induced in immature mouse DC by S. mansoni eggs or schistosomula. Although SLA abrogated the transcription of many genes implicated in DC functions, eggs caused myeloid DC to produce IFN-beta. Autocrine/paracrine signaling through the type I IFN receptor in response to eggs was necessary for the induction of known IFN-responsive genes and enhanced the synthesis of key inflammatory products. Taken as a whole, our data provide molecular insights into the immune evasion mechanism of schistosomula and suggest an unexpected role for type I IFN in the innate response to helminth eggs

Trottein, F., Pavelka, N., Vizzardelli, C., Angeli, V., Zouain, C., Pelizzola, M., et al. (2004). A Type I IFN-Dependent Pathway Induced by Schistosoma mansoni Eggs in Mouse Myeloid Dendritic Cells Generates an Inflammatory Signature. JOURNAL OF IMMUNOLOGY, 172(5), 3011-3017 [10.4049/jimmunol.172.5.3011].

A Type I IFN-Dependent Pathway Induced by Schistosoma mansoni Eggs in Mouse Myeloid Dendritic Cells Generates an Inflammatory Signature

Pelizzola, M;Granucci, F;Ricciardi-Castagnoli, P
2004

Abstract

Schistosomes are helminth parasites that display a dual impact on the immune system of their hosts. Although the larval stage, also known as schistosomulum, appears to subvert the host defenses, the egg stage induces strong inflammatory reactions. Given the pivotal role of dendritic cells (DC) in initiating and regulating immune responses, we compared the distinct transcriptional programs induced in immature mouse DC by S. mansoni eggs or schistosomula. Although SLA abrogated the transcription of many genes implicated in DC functions, eggs caused myeloid DC to produce IFN-beta. Autocrine/paracrine signaling through the type I IFN receptor in response to eggs was necessary for the induction of known IFN-responsive genes and enhanced the synthesis of key inflammatory products. Taken as a whole, our data provide molecular insights into the immune evasion mechanism of schistosomula and suggest an unexpected role for type I IFN in the innate response to helminth eggs
Articolo in rivista - Articolo scientifico
Autocrine Communication; Schistosoma mansoni; Cell Line; Oligonucleotide Array Sequence Analysis; Gene Expression Profiling; Larva; Membrane Proteins; Mice, Knockout; Animals; Ovum; Myeloid Cells; Dendritic Cells; Inflammation; Interferon-beta; Paracrine Communication; Signal Transduction; Mice; Receptor, Interferon alpha-beta; Receptors, Interferon; Transcription, Genetic; Multigene Family
English
2004
172
5
3011
3017
none
Trottein, F., Pavelka, N., Vizzardelli, C., Angeli, V., Zouain, C., Pelizzola, M., et al. (2004). A Type I IFN-Dependent Pathway Induced by Schistosoma mansoni Eggs in Mouse Myeloid Dendritic Cells Generates an Inflammatory Signature. JOURNAL OF IMMUNOLOGY, 172(5), 3011-3017 [10.4049/jimmunol.172.5.3011].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/13072
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