SAVINO, ANGELA MARIA
SAVINO, ANGELA MARIA
DIPARTIMENTO DI MEDICINA E CHIRURGIA (SCHOOL OF MEDICINE AND SURGERY)
Biallelic PI4KA Mutations Disrupt B-Cell Metabolism and Cause B-Cell Lymphopenia and Hypogammaglobulinemia
2025 Saettini, F; Guerra, F; Mauri, M; Salter, C; Adam, M; Adams, D; Baple, E; Barredo, E; Bhatia, S; Borkhardt, A; Brusco, A; Bugarin, C; Chinello, C; Crosby, A; D'Souza, P; Denti, V; Fazio, G; Giuliani, S; Kuehn, H; Amel, H; Elmi, A; Lo, B; Malighetti, F; Mandrile, G; Martín-Nalda, A; Mefford, H; Moratto, D; Emam Mousavi, F; Nelson, Z; Gutiérrez-Solana, L; Macnamara, E; Michaud, V; O'Leary, M; Pagani, L; Pavinato, L; Santamaria, P; Planas-Serra, L; Quadri, M; Raspall-Chaure, M; Rebellato, S; Rosenzweig, S; Roubertie, A; Holzinger, D; Deal, C; Vockley, C; Savino, A; L. Stoddard, J; Uhlig, H; Pujol, A; Magni, F; Paglia, G; Cazzaniga, G; Piazza, R; Barberis, M; Biondi, A
Unlocking the Heterogeneity in Acute Leukaemia: Dissection of Clonal Architecture and Metabolic Properties for Clinical Interventions
2025 Capelletti, M; Montini, O; Ruini, E; Tettamanti, S; Savino, A; Sarno, J
Synergistic drug interactions of the histone deacetylase inhibitor givinostat (ITF2357) in CRLF2-rearranged pediatric B-cell precursor acute lymphoblastic leukemia identified by high-throughput drug screening
2024 Oikonomou, A; Watrin, T; Valsecchi, L; Scharov, K; Savino, A; Schliehe-Diecks, J; Bardini, M; Fazio, G; Bresolin, S; Biondi, A; Borkhardt, A; Bhatia, S; Cazzaniga, G; Palmi, C
Targeting glycolysis to rescue 2-hydroxyglutarate immunosuppressive effects in dendritic cells and acute myeloid leukemia
2024 Savino, A; Stuani, L
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
2023 Oikonomou, A; Valsecchi, L; Quadri, M; Watrin, T; Scharov, K; Procopio, S; Tu, J; Vogt, M; Savino, A; Silvestri, D; Valsecchi, M; Biondi, A; Borkhardt, A; Bhatia, S; Cazzaniga, G; Fazio, G; Bardini, M; Palmi, C
An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia
2022 Geron, I; Savino, A; Fishman, H; Tal, N; Brown, J; Turati, V; James, C; Sarno, J; Hameiri-Grossman, M; Lee, Y; Rein, A; Maniriho, H; Birger, Y; Zemlyansky, A; Muler, I; Davis, K; Marcu-Malina, V; Mattson, N; Parnas, O; Wagener, R; Fischer, U; Barata, J; Jamieson, C; Müschen, M; Chen, C; Borkhardt, A; Kirsch, I; Nagler, A; Enver, T; Izraeli, S
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120
2022 Fazio, G; Bresolin, S; Silvestri, D; Quadri, M; Saitta, C; Vendramini, E; Buldini, B; Palmi, C; Bardini, M; Grioni, A; Rigamonti, S; Galbiati, M; Mecca, S; Savino, A; Peloso, A; Tu, J; Bhatia, S; Borkhardt, A; Micalizzi, C; Lo Nigro, L; Locatelli, F; Conter, V; Rizzari, C; Valsecchi, M; Te Kronnie, G; Biondi, A; Cazzaniga, G
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells
2021 Jeong, S; Savino, A; Chirayil, R; Barin, E; Cheng, Y; Park, S; Schurer, A; Mullarky, E; Cantley, L; Kharas, M; Keshari, K
Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes
2021 Granatiero, V; Sayles, N; Savino, A; Konrad, C; Kharas, M; Kawamata, H; Manfredi, G
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation
2021 Cheng, Y; Xie, W; Pickering, B; Chu, K; Savino, A; Yang, X; Luo, H; Nguyen, D; Mo, S; Barin, E; Velleca, A; Rohwetter, T; Patel, D; Jaffrey, S; Kharas, M
Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia
2021 Prieto, C; Nguyen, D; Liu, Z; Wheat, J; Perez, A; Gourkanti, S; Chou, T; Barin, E; Velleca, A; Rohwetter, T; Chow, A; Taggart, J; Savino, A; Hoskova, K; Dhodapkar, M; Schurer, A; Barlowe, T; Vu, L; Leslie, C; Steidl, U; Rabadan, R; Kharas, M
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells
2020 Nguyen, D; Lu, Y; Chu, K; Yang, X; Park, S; Choo, Z; Chin, C; Prieto, C; Schurer, A; Barin, E; Savino, A; Gourkanti, S; Patel, P; Vu, L; Leslie, C; Kharas, M
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase
2020 Savino, A; Fernandes, S; Olivares, O; Zemlyansky, A; Cousins, A; Markert, E; Barel, S; Geron, I; Frishman, L; Birger, Y; Eckert, C; Tumanov, S; Mackay, G; Kamphorst, J; Herzyk, P; Fernández-García, J; Abramovich, I; Mor, I; Bardini, M; Barin, E; Janaki-Raman, S; Cross, J; Kharas, M; Gottlieb, E; Izraeli, S; Halsey, C
Pharmacological administration of recombinant human AMH rescues ovarian reserve and preserves fertility in a mouse model of chemotherapy, without interfering with anti-tumoural effects
2019 Roness, H; Spector, I; Leichtmann-Bardoogo, Y; Savino, A; Dereh-Haim, S; Meirow, D
Antileukemic efficacy of BET inhibitor in a preclinical mouse model of MLL-AF4 + infant ALL
2018 Bardini, M; Trentin, L; Rizzo, F; Vieri, M; Savino, A; Castro, P; Fazio, G; Van Roon, E; Kerstjens, M; Smithers, N; Prinjha, R; Kronnie, G; Basso, G; Stam, R; Pieters, R; Biondi, A; Cazzaniga, G
SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia
2018 Sarno, J; Savino, A; Buracchi, C; Palmi, C; Pinto, S; Bugarin, C; Jager, A; Bresolin, S; Barber, R; Silvestri, D; Israeli, S; Dyer, M; Cazzaniga, G; Nolan, G; Biondi, A; Davis, K; Gaipa, G
Interleukin-7 signaling as a therapeutic target in acute lymphoblastic leukemia
2017 Savino, A; Izraeli, S
Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome
2017 Schwartzman, O; Savino, A; Gombert, M; Palmi, C; Cario, G; Schrappe, M; Eckert, C; von Stackelberg, A; Huang, J; Hameiri-Grossman, M; Avigad, S; Te Kronnie, G; Geron, I; Birger, Y; Rein, A; Zarfati, G; Fischer, U; Mukamel, Z; Stanulla, M; Biondi, A; Cazzaniga, G; Vetere, A; Wagner, B; Chen, Z; Chen, S; Tanay, A; Borkhardt, A; Izraeli, S
The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL
2017 Savino, A; Sarno, J; Trentin, L; Vieri, M; Fazio, G; Bardini, M; Bugarin, C; Fossati, G; Davis, K; Gaipa, G; Izraeli, S; Meyer, L; Nolan, G; Biondi, A; Te Kronnie, G; Palmi, C; Cazzaniga, G
CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia
2016 Palmi, C; Savino, A; Silvestri, D; Bronzini, I; Cario, G; Paganin, M; Buldini, B; Galbiati, M; Muckenthaler, M; Bugarin, C; Mina, P; Nagel, S; Barisone, E; Casale, F; Locatelli, F; Nigro, L; Micalizzi, C; Parasole, R; Pession, A; Putti, M; Santoro, N; Testi, A; Ziino, O; Kulozik, A; Zimmermann, M; Schrappe, M; Villa, A; Gaipa, G; Basso, G; Biondi, A; Valsecchi, M; Stanulla, M; Conter, V; Kronnie, G; Cazzaniga, G