Several factors are predictive of treatment-free remission (TFR) in chronic myeloid leukemia (CML), but few data exist on the role of natural killer (NK) cells and their killer-cell immunoglobulin-like receptors (KIRs). KIR and human leukocyte antigen (HLA) genotypes were investigated in 36 CML patients who discontinued tyrosine kinase inhibitor (TKI) treatment after achieving deep molecular response (MR4.5). Cumulative TFR was significantly higher in patients homozygous for KIR A haplotype (85.7% vs. 45.5%; p = 0.029). Younger age, Bx haplotype, and the combination KIR3DS1/KIR3DL1 present/HLA-Bw4 present were significantly associated with relapse. KIR genotypes could prove useful in identifying patients that are likely to maintain MR4.5 after discontinuing TKI treatment.

Caocci, G., Martino, B., Greco, M., Abruzzese, E., Trawinska, M., Lai, S., et al. (2015). Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patients. EXPERIMENTAL HEMATOLOGY, 43(12), 1015-1018.e1 [10.1016/j.exphem.2015.08.004].

Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patients

GAMBACORTI PASSERINI, CARLO
Penultimo
;
2015

Abstract

Several factors are predictive of treatment-free remission (TFR) in chronic myeloid leukemia (CML), but few data exist on the role of natural killer (NK) cells and their killer-cell immunoglobulin-like receptors (KIRs). KIR and human leukocyte antigen (HLA) genotypes were investigated in 36 CML patients who discontinued tyrosine kinase inhibitor (TKI) treatment after achieving deep molecular response (MR4.5). Cumulative TFR was significantly higher in patients homozygous for KIR A haplotype (85.7% vs. 45.5%; p = 0.029). Younger age, Bx haplotype, and the combination KIR3DS1/KIR3DL1 present/HLA-Bw4 present were significantly associated with relapse. KIR genotypes could prove useful in identifying patients that are likely to maintain MR4.5 after discontinuing TKI treatment.
Articolo in rivista - Articolo scientifico
TFR, CML
English
1015
1018.e1
4
Caocci, G., Martino, B., Greco, M., Abruzzese, E., Trawinska, M., Lai, S., et al. (2015). Killer immunoglobulin-like receptors can predict TKI treatment-free remission in chronic myeloid leukemia patients. EXPERIMENTAL HEMATOLOGY, 43(12), 1015-1018.e1 [10.1016/j.exphem.2015.08.004].
Caocci, G; Martino, B; Greco, M; Abruzzese, E; Trawinska, M; Lai, S; Ragatzu, P; Galimberti, S; Baratè, C; Mulas, O; Labate, C; Littera, R; Carcassi, C; GAMBACORTI PASSERINI, C; La Nasa, G
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/99904
Citazioni
  • Scopus 46
  • ???jsp.display-item.citation.isi??? 42
Social impact