Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein implicated in a variety of tumors, both solid and hematological. Few years ago crizotinib, an inhibitor of the receptor tyrosine kinases c-Met and ALK, demonstrated its activity in ALK positive non-smallcell lung cancer and other tumors with excellent toxicity profile. Subsequently several ALK inhibitors have been developed, offering new personalized treatment options. This review addresses some clinical considerations on the use of ALK inhibitors in ALK positive tumors and on the development of resistance to them.

Farina, F., GAMBACORTI PASSERINI, C. (2016). ALK inhibitors for clinical use in cancer therapy. FRONTIERS IN BIOSCIENCE, 8(1), 46-60 [10.2741/750].

ALK inhibitors for clinical use in cancer therapy

FARINA, FRANCESCA
Primo
;
GAMBACORTI PASSERINI, CARLO
Ultimo
2016

Abstract

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein implicated in a variety of tumors, both solid and hematological. Few years ago crizotinib, an inhibitor of the receptor tyrosine kinases c-Met and ALK, demonstrated its activity in ALK positive non-smallcell lung cancer and other tumors with excellent toxicity profile. Subsequently several ALK inhibitors have been developed, offering new personalized treatment options. This review addresses some clinical considerations on the use of ALK inhibitors in ALK positive tumors and on the development of resistance to them.
Articolo in rivista - Review Essay
ALK-rearranged tumors; Crizotinib; Crizotinib-resistance; Next-generation ALK inhibitors; Review;
ALK, crizotinib
English
46
60
15
Farina, F., GAMBACORTI PASSERINI, C. (2016). ALK inhibitors for clinical use in cancer therapy. FRONTIERS IN BIOSCIENCE, 8(1), 46-60 [10.2741/750].
Farina, F; GAMBACORTI PASSERINI, C
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/99899
Citazioni
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
Social impact