Background: The clinical presentation of amyotrophic lateral sclerosis (ALS) is characterized by high heterogeneity, the greatest part of which still remains unexplained. Objective: To assess serum levels of brain-derived neurotrophic factor (BDNF) in ALS patients, implementing a multidimensional characterization focused on four a priori chosen elements of phenotypic variability: ALS bulbar/spinal subtype, cognitive impairment, mood dysfunction and disease progression speed. Methods: Serum samples were obtained from 45 ALS outpatients (16% bulbar onset) and 22 healthy controls. Each patient underwent the Montreal Cognitive Assessment (MoCA) and the Beck Depression Inventory (BDI), and disease progression speed was estimated by calculating the decay of the ALSFRS-R score over time. Results: BDNF serum levels did not differ between patients and controls, although ∼25% lower levels characterized those patients carrying a depressive trait. Finally, BDNF serum levels were significantly lower in ALS patients expressing lower ALSFRS-R scores (r = 0.39, p < 0.01). No differences were found when considering cognitive impairment, disease progression speed and site of onset. Conclusion: BDNF serum levels might mark and possibly contribute in part to ALS phenotypic variability.

Tremolizzo L., Pellegrini A., Conti E., Arosio A., Gerardi F., Lunetta C., et al. (2016). BDNF serum levels with respect to multidimensional assessment in amyotrophic lateral sclerosis. NEURODEGENERATIVE DISEASES, 16(3-4), 192-198 [10.1159/000441916].

BDNF serum levels with respect to multidimensional assessment in amyotrophic lateral sclerosis

TREMOLIZZO, LUCIO
Primo
;
CONTI, ELISA;AROSIO, ALESSANDRO;APPOLLONIO, ILDEBRANDO
Penultimo
;
FERRARESE, CARLO
Ultimo
2016

Abstract

Background: The clinical presentation of amyotrophic lateral sclerosis (ALS) is characterized by high heterogeneity, the greatest part of which still remains unexplained. Objective: To assess serum levels of brain-derived neurotrophic factor (BDNF) in ALS patients, implementing a multidimensional characterization focused on four a priori chosen elements of phenotypic variability: ALS bulbar/spinal subtype, cognitive impairment, mood dysfunction and disease progression speed. Methods: Serum samples were obtained from 45 ALS outpatients (16% bulbar onset) and 22 healthy controls. Each patient underwent the Montreal Cognitive Assessment (MoCA) and the Beck Depression Inventory (BDI), and disease progression speed was estimated by calculating the decay of the ALSFRS-R score over time. Results: BDNF serum levels did not differ between patients and controls, although ∼25% lower levels characterized those patients carrying a depressive trait. Finally, BDNF serum levels were significantly lower in ALS patients expressing lower ALSFRS-R scores (r = 0.39, p < 0.01). No differences were found when considering cognitive impairment, disease progression speed and site of onset. Conclusion: BDNF serum levels might mark and possibly contribute in part to ALS phenotypic variability.
Articolo in rivista - Articolo scientifico
Amyotrophic lateral sclerosis; Brain-derived neurotrophic factor; Cognitive impairment; Depression;
ALS, BDNF, multidimensional, cognitive, mood, functional
English
192
198
7
Tremolizzo L., Pellegrini A., Conti E., Arosio A., Gerardi F., Lunetta C., et al. (2016). BDNF serum levels with respect to multidimensional assessment in amyotrophic lateral sclerosis. NEURODEGENERATIVE DISEASES, 16(3-4), 192-198 [10.1159/000441916].
Tremolizzo, L; Pellegrini, A; Conti, E; Arosio, A; Gerardi, F; Lunetta, C; Magni, P; Appollonio, I; Ferrarese, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/99508
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