Objectives-Right heart function and mechanics have not been investigated in patients with subclinical hyperthyroidism. Our aim was to investigate right ventricular (RV) and right atrial (RA) function and deformation as evaluated by 3-dimensional echocardiography (3DE) and speckle-tracking 2-dimensional echocardiography (2DE) in these individuals. Methods-We included 39 untreated women with endogenous subclinical hyperthyroidism and 39 healthy women matched by age. All participants underwent laboratory analyses that included thyroid hormone levels and comprehensive 2DE and 3DE examinations. Results-Three-dimensional echocardiographic RV volumes were significantly elevated in the patients with subclinical hyperthyroidism (P < .05), whereas the 3DE RV ejection fraction was reduced in this group, but with borderline significance. Twodimensional echocardiographic longitudinal RV and RA strain were significantly reduced in the patients with subclinical hyperthyroidism. Two-dimensional echocardiographic RV systolic and early diastolic strain rates were reduced, whereas late diastolic strain rates were increased in the patients with subclinical hyperthyroidism. The same changes were detected in RA mechanics among the patients with subclinical hyperthyroidism. The thyrotropin (TSH) level correlated with the left ventricular mass index, transmitral early diastolic peak flow velocity (E)/late diastolic flow velocity (A) ratio, tricuspid E/A ratio, 2DE RV global strain, 2DE RA, strain, and 3DE RV enddiastolic volume. A multivariate regression analysis showed that the mitral E/A ratio, 2DE RV global strain, and 3DE RV end-diastolic volume were independently associated with the TSH level. Conclusions-Right ventricular and RA function as evaluated by 3DE and speckletracking 2DE is significantly impaired in patients with subclinical hyperthyroidism. The TSH level correlated with parameters for RV function and mechanics in the whole study population.

Tadic, M., Celic, V., Cuspidi, C., Ilic, S., Zivanovic, V., & Marjanovic, T. (2016). How does subclinical hyperthyroidism affect right heart function and mechanics?. JOURNAL OF ULTRASOUND IN MEDICINE, 35(2), 287-295 [10.7863/ultra.15.03054].

How does subclinical hyperthyroidism affect right heart function and mechanics?

Cuspidi, C
;
2016

Abstract

Objectives-Right heart function and mechanics have not been investigated in patients with subclinical hyperthyroidism. Our aim was to investigate right ventricular (RV) and right atrial (RA) function and deformation as evaluated by 3-dimensional echocardiography (3DE) and speckle-tracking 2-dimensional echocardiography (2DE) in these individuals. Methods-We included 39 untreated women with endogenous subclinical hyperthyroidism and 39 healthy women matched by age. All participants underwent laboratory analyses that included thyroid hormone levels and comprehensive 2DE and 3DE examinations. Results-Three-dimensional echocardiographic RV volumes were significantly elevated in the patients with subclinical hyperthyroidism (P < .05), whereas the 3DE RV ejection fraction was reduced in this group, but with borderline significance. Twodimensional echocardiographic longitudinal RV and RA strain were significantly reduced in the patients with subclinical hyperthyroidism. Two-dimensional echocardiographic RV systolic and early diastolic strain rates were reduced, whereas late diastolic strain rates were increased in the patients with subclinical hyperthyroidism. The same changes were detected in RA mechanics among the patients with subclinical hyperthyroidism. The thyrotropin (TSH) level correlated with the left ventricular mass index, transmitral early diastolic peak flow velocity (E)/late diastolic flow velocity (A) ratio, tricuspid E/A ratio, 2DE RV global strain, 2DE RA, strain, and 3DE RV enddiastolic volume. A multivariate regression analysis showed that the mitral E/A ratio, 2DE RV global strain, and 3DE RV end-diastolic volume were independently associated with the TSH level. Conclusions-Right ventricular and RA function as evaluated by 3DE and speckletracking 2DE is significantly impaired in patients with subclinical hyperthyroidism. The TSH level correlated with parameters for RV function and mechanics in the whole study population.
Articolo in rivista - Articolo scientifico
2-dimensional speckle tracking; 3-dimensional echocardiography; Echocardiography; Right ventricle; Subclinical hyperthyroidism;
Hyperthyroidism , Right Heart Function
English
287
295
9
Tadic, M., Celic, V., Cuspidi, C., Ilic, S., Zivanovic, V., & Marjanovic, T. (2016). How does subclinical hyperthyroidism affect right heart function and mechanics?. JOURNAL OF ULTRASOUND IN MEDICINE, 35(2), 287-295 [10.7863/ultra.15.03054].
Tadic, M; Celic, V; Cuspidi, C; Ilic, S; Zivanovic, V; Marjanovic, T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/99013
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