We previously demonstrated that the intraperitoneal administration of palmitoylethanolamide (PEA) in mice with chronic constriction injury of the sciatic nerve evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Since diabetic neuropathy is one of the most common long-term complications of diabetes, we explored the ability of PEA to also relief this kind of chronic pain, employing the well established streptozotocin-induced animal model of type 1 diabetes. Our findings demonstrated that PEA relieves mechanical allodynia, counteracts nerve growth factor deficit, improves insulin level, preserves Langherans islet morphology reducing the development of insulitis in diabetic mice. These results suggest that PEA could be effective in type1 -diabetic patients not only as pain reliever but also in controlling the development of pathology.

Donvito, G., Bettoni, I., Comelli, F., Colombo, A., & Costa, B. (2015). Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetes. CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS, 14(4), 452-462 [10.2174/1871527314666150429111537].

Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetes

DONVITO, GIULIA
Primo
;
BETTONI, ISABELLA
Secondo
;
COMELLI, FRANCESCA;COLOMBO, ANITA EMILIA
Penultimo
;
COSTA, BARBARA SIMONA
2015

Abstract

We previously demonstrated that the intraperitoneal administration of palmitoylethanolamide (PEA) in mice with chronic constriction injury of the sciatic nerve evoked a relief of both thermal hyperalgesia and mechanical allodynia in neuropathic mice. Since diabetic neuropathy is one of the most common long-term complications of diabetes, we explored the ability of PEA to also relief this kind of chronic pain, employing the well established streptozotocin-induced animal model of type 1 diabetes. Our findings demonstrated that PEA relieves mechanical allodynia, counteracts nerve growth factor deficit, improves insulin level, preserves Langherans islet morphology reducing the development of insulitis in diabetic mice. These results suggest that PEA could be effective in type1 -diabetic patients not only as pain reliever but also in controlling the development of pathology.
No
Articolo in rivista - Articolo scientifico
Scientifica
Allodynia; Diabetes; Endocannabinoid; Insulin; Insulitis; Mast cell; Nerve growth factor; Neuropathy; Oxidative stress; Palmitoylethanolamide; Neuroscience (all); Pharmacology
English
452
462
11
Donvito, G., Bettoni, I., Comelli, F., Colombo, A., & Costa, B. (2015). Palmitoylethanolamide relieves pain and preserves pancreatic islet cells in a murine model of diabetes. CNS & NEUROLOGICAL DISORDERS. DRUG TARGETS, 14(4), 452-462 [10.2174/1871527314666150429111537].
Donvito, G; Bettoni, I; Comelli, F; Colombo, A; Costa, B
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/98548
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