Background: Host genetic factors are thought to modulated the severity of disease caused by infection with the 2009 H1N1 pandemic influenza virus (H1N1pdm09). The human CCR5 gene encodes a cytokine receptor important for cell-mediated immune response against H1N1pdm09. A 32-bp polymorphic deletion in the coding sequence of CCR5, the so-called CCR5Δ32 allele, segregates in populations of European ancestry with a frequency of 8-15%. A high proportion of CCR5Δ32 heterozygotes was reported in a sample of white Canadian critically-ill H1N1pdm09 infected subjects, suggesting an association with disease severity. Methods. We recruited 29 H1N1pdm09 infected subjects from Southern Europe (mostly Italians) with a wide clinical spectrum of disease symptoms; the sample included 7 subjects who developed acute respiratory distress syndrome requiring extracorporeal membrane oxygenation. The CCR5Δ32 variant was genotyped in all subjects. Results: The CCR5Δ32 allele was found in one single subject, who developed a very mild form and was not hospitalized. Conclusions: The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a severe disease course.

Sironi, M., Cagliani, R., Pontremoli, C., Rossi, M., Migliorino, G., Clerici, M., et al. (2014). The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection. BMC RESEARCH NOTES, 7(1), 504 [10.1186/1756-0500-7-504].

The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection

Sironi, M;ROSSI, MARIANNA;GORI, ANDREA
Ultimo
2014

Abstract

Background: Host genetic factors are thought to modulated the severity of disease caused by infection with the 2009 H1N1 pandemic influenza virus (H1N1pdm09). The human CCR5 gene encodes a cytokine receptor important for cell-mediated immune response against H1N1pdm09. A 32-bp polymorphic deletion in the coding sequence of CCR5, the so-called CCR5Δ32 allele, segregates in populations of European ancestry with a frequency of 8-15%. A high proportion of CCR5Δ32 heterozygotes was reported in a sample of white Canadian critically-ill H1N1pdm09 infected subjects, suggesting an association with disease severity. Methods. We recruited 29 H1N1pdm09 infected subjects from Southern Europe (mostly Italians) with a wide clinical spectrum of disease symptoms; the sample included 7 subjects who developed acute respiratory distress syndrome requiring extracorporeal membrane oxygenation. The CCR5Δ32 variant was genotyped in all subjects. Results: The CCR5Δ32 allele was found in one single subject, who developed a very mild form and was not hospitalized. Conclusions: The CCR5Δ32 allele was not found to be associated with the risk of H1N1pdm09 infection or with a severe disease course.
Articolo in rivista - Articolo scientifico
CCR5Δ32; Disease severity; H1N1pdm09 infection; Base Sequence; DNA Primers; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Polymerase Chain Reaction; Receptors, CCR5; Alleles; Genetic Predisposition to Disease; Biochemistry, Genetics and Molecular Biology (all); Medicine (all)
English
2014
7
1
504
504
none
Sironi, M., Cagliani, R., Pontremoli, C., Rossi, M., Migliorino, G., Clerici, M., et al. (2014). The CCR5Δ32 allele is not a major predisposing factor for severe H1N1pdm09 infection. BMC RESEARCH NOTES, 7(1), 504 [10.1186/1756-0500-7-504].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/96687
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