Background: Despite recent development of direct acting antivirals for treatment of hepatitis C, the current standard of care may still include pegylated-interferon, which is associated with frequent and, at times, serious adverse events. Case presentation: Here we report for the first time on a severe case of classic neuromyelitis optica (i.e., optic-spinal form) in a 32 year-old Egyptian man with chronic hepatitis C treated with pegylated-interferon α2a for 4 months. Conclusions: Treating physicians must be alerted on rare but important unexpected complications of interferon, in order to consider carefully its use especially when they deal with patients not in dire need of urgent treatment.

Mangioni, D., Soria, A., Brighina, L., Bandera, A., Ferrarese, C., Gori, A. (2014). A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon α. BMC PHARMACOLOGY & TOXICOLOGY, 15(1) [10.1186/2050-6511-15-56].

A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon α

SORIA, ALESSANDRO
Secondo
;
BRIGHINA, LAURA;BANDERA, ALESSANDRA;FERRARESE, CARLO
Penultimo
;
GORI, ANDREA
Ultimo
2014

Abstract

Background: Despite recent development of direct acting antivirals for treatment of hepatitis C, the current standard of care may still include pegylated-interferon, which is associated with frequent and, at times, serious adverse events. Case presentation: Here we report for the first time on a severe case of classic neuromyelitis optica (i.e., optic-spinal form) in a 32 year-old Egyptian man with chronic hepatitis C treated with pegylated-interferon α2a for 4 months. Conclusions: Treating physicians must be alerted on rare but important unexpected complications of interferon, in order to consider carefully its use especially when they deal with patients not in dire need of urgent treatment.
Articolo in rivista - Articolo scientifico
Adverse events; HCV; Neuromyelitis optica; Pegylated-interferonα;
Adult; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Neuromyelitis Optica; Polyethylene Glycols; Recombinant Proteins; Medicine (all)
English
30-set-2014
2014
15
1
56
open
Mangioni, D., Soria, A., Brighina, L., Bandera, A., Ferrarese, C., Gori, A. (2014). A case of classic neuromyelitis optica (Devic's syndrome) triggered by pegylated-interferon α. BMC PHARMACOLOGY & TOXICOLOGY, 15(1) [10.1186/2050-6511-15-56].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/96676
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