During the past decades, a growing interest has been raised in evaluating nontuberculous mycobacteria (NTM) in patients with noncystic fibrosis bronchiectasis (NCFBE). This paper reviews several aspects of the correlations between NTM and NCFBE, including pathogenesis, radiological features, diagnosis, and management. Bronchiectasis and NTM lung disease are connected, but which one comes first is still an unresolved question. The rate of NTM lung disease in NCFBE varies through the studies, from 5% to 30%. The most frequent species isolated is MAC. NCFBE patients affected by NTM infection frequently present coinfections, including both other different NTM species and microorganisms, such as P. aeruginosa. Once a diagnosis of NTM disease has been reached, the initiation of therapy is not always mandatory. NTM species isolated, patients' conditions, and disease severity and its evolution should be considered. Risk factors for disease progression in NCFBE patients with NTM are low body mass index, cavitary disease, consolidations, and macrolide resistance at presentation.

Bonaiti, G., Pesci, A., Marruchella, A., Lapadula, G., Gori, A., Aliberti, S. (2015). Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis. BIOMED RESEARCH INTERNATIONAL, 2015, 1-8 [10.1155/2015/197950].

Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis

BONAITI, GIULIA
Primo
;
PESCI, ALBERTO
Secondo
;
LAPADULA, GIUSEPPE;GORI, ANDREA
Penultimo
;
ALIBERTI, STEFANO
2015

Abstract

During the past decades, a growing interest has been raised in evaluating nontuberculous mycobacteria (NTM) in patients with noncystic fibrosis bronchiectasis (NCFBE). This paper reviews several aspects of the correlations between NTM and NCFBE, including pathogenesis, radiological features, diagnosis, and management. Bronchiectasis and NTM lung disease are connected, but which one comes first is still an unresolved question. The rate of NTM lung disease in NCFBE varies through the studies, from 5% to 30%. The most frequent species isolated is MAC. NCFBE patients affected by NTM infection frequently present coinfections, including both other different NTM species and microorganisms, such as P. aeruginosa. Once a diagnosis of NTM disease has been reached, the initiation of therapy is not always mandatory. NTM species isolated, patients' conditions, and disease severity and its evolution should be considered. Risk factors for disease progression in NCFBE patients with NTM are low body mass index, cavitary disease, consolidations, and macrolide resistance at presentation.
Articolo in rivista - Review Essay
Biochemistry, Genetics and Molecular Biology (all); Immunology and Microbiology (all)
English
1
8
8
Bonaiti, G., Pesci, A., Marruchella, A., Lapadula, G., Gori, A., Aliberti, S. (2015). Nontuberculous Mycobacteria in Noncystic Fibrosis Bronchiectasis. BIOMED RESEARCH INTERNATIONAL, 2015, 1-8 [10.1155/2015/197950].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/96631
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