We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreasedAβ40 andAβ42. After treatment, focal symptomatology disappeared, andWMLand anti-Aβautoantibodies decreased. TheAPOEε4 allelewas overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
Carmona Iragui, M., Fernández Arcos, A., Alcolea, D., Piazza, F., Morenas, E., Antón Aguirre, S., et al. (2016). Cerebrospinal Fluid Anti-Amyloid-Beta; Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation. JOURNAL OF ALZHEIMER'S DISEASE, 50(1), 1-7 [10.3233/JAD-150614].
Cerebrospinal Fluid Anti-Amyloid-Beta; Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation
PIAZZA, FABRIZIO;
2016
Abstract
We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-Aβ autoantibodies, t-Tau, and p-Tau and decreasedAβ40 andAβ42. After treatment, focal symptomatology disappeared, andWMLand anti-Aβautoantibodies decreased. TheAPOEε4 allelewas overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-Aβ autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.
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