AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands. Three cases are reported of epithelial-myoepithelial carcinoma of the minor salivary glands, with the goal of better defining this entity. PATIENTS AND METHODS: All three cases showed a characteristic nodular/multinodular growth pattern and classic biphasic tubular histology. All parts of each tumor were surrounded by a myoepithelial cell rim and there was evidence of invasion. RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10). The tumor cells were negative for vimentin, alpha-smooth muscle actin (SMA) (except one case), glial fibrillar acid protein (GFAP) and MIB1. The tumors were resected completely with wide margins and no recurrence or metastasis had occurred from 6 to 15 months after surgery. CONCLUSION: Three cases of minor salivary gland tumors are described and the differential diagnosis underlined in relation to benign myoepithelioma. The characteristic morphological and immunohistochemical features aided diagnosis of these biphasic tumors.

Angiero, F., Sozzi, D., Seramondi, R., & Valente, M.G. (2009). Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. ANTICANCER RESEARCH, 29(11), 4703-4709.

Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features

SOZZI, DAVIDE;
2009

Abstract

AIMS: Epithelial-myoepithelial carcinoma (EMC) is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in the minor salivary glands. Three cases are reported of epithelial-myoepithelial carcinoma of the minor salivary glands, with the goal of better defining this entity. PATIENTS AND METHODS: All three cases showed a characteristic nodular/multinodular growth pattern and classic biphasic tubular histology. All parts of each tumor were surrounded by a myoepithelial cell rim and there was evidence of invasion. RESULTS: Immunohistochemical analysis showed the tumor cells to be weakly positive for S100, cytokeratin (CK) CK5/6, CK7, CKAE-1/AE-3 and strongly positive for epithelial membrane antigen (EMA) and p63; they were focally positive for calponin and acute lymphoblastic leukemia antigen (CD10). The tumor cells were negative for vimentin, alpha-smooth muscle actin (SMA) (except one case), glial fibrillar acid protein (GFAP) and MIB1. The tumors were resected completely with wide margins and no recurrence or metastasis had occurred from 6 to 15 months after surgery. CONCLUSION: Three cases of minor salivary gland tumors are described and the differential diagnosis underlined in relation to benign myoepithelioma. The characteristic morphological and immunohistochemical features aided diagnosis of these biphasic tumors.
Articolo in rivista - Articolo scientifico
Scientifica
epithelial-myoephithelial carcinoma, minor salivary glands, histological variants, immunohistochemistry
English
Angiero, F., Sozzi, D., Seramondi, R., & Valente, M.G. (2009). Epithelial-myoepithelial carcinoma of the minor salivary glands: immunohistochemical and morphological features. ANTICANCER RESEARCH, 29(11), 4703-4709.
Angiero, F; Sozzi, D; Seramondi, R; Valente, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/9308
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