A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel showed in vitro activity in inhibiting the nucleotide exchange on Ras and were toxic for some human cancer cell lines

Müeller, C., Gomez Zurita Frau, M., Ballinari, D., Colombo, S., Bitto, A., Martegani, E., et al. (2009). Design, Synthesis and Biological Evaluation of Levoglucosenone-derived Ras Activation Inhibitors. CHEMMEDCHEM, 4, 524-528 [10.1002/cmdc.200800416].

Design, Synthesis and Biological Evaluation of Levoglucosenone-derived Ras Activation Inhibitors

COLOMBO, SONIA;MARTEGANI, ENZO;AIROLDI, CRISTINA;PERI, FRANCESCO
2009

Abstract

A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel showed in vitro activity in inhibiting the nucleotide exchange on Ras and were toxic for some human cancer cell lines
Articolo in rivista - Articolo scientifico
Ras, antitumor drugs, levoglucosenone
English
524
528
Müeller, C., Gomez Zurita Frau, M., Ballinari, D., Colombo, S., Bitto, A., Martegani, E., et al. (2009). Design, Synthesis and Biological Evaluation of Levoglucosenone-derived Ras Activation Inhibitors. CHEMMEDCHEM, 4, 524-528 [10.1002/cmdc.200800416].
Müeller, C; Gomez Zurita Frau, M; Ballinari, D; Colombo, S; Bitto, A; Martegani, E; Airoldi, C; van Neuren, A; Stein, M; Weiser, J; Battistini, C; Peri, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/8599
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