A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel showed in vitro activity in inhibiting the nucleotide exchange on Ras and were toxic for some human cancer cell lines
Müeller, C., Gomez Zurita Frau, M., Ballinari, D., Colombo, S., Bitto, A., Martegani, E., et al. (2009). Design, Synthesis and Biological Evaluation of Levoglucosenone-derived Ras Activation Inhibitors. CHEMMEDCHEM, 4, 524-528 [10.1002/cmdc.200800416].