IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
IRIS contiene inoltre alcuni moduli dedicati alla registrazione dei progetti e dei contratti, e alla reportistica avanzata per le attività di valutazione della ricerca
EnglishOBJECTIVE:: To investigate whether perioperative intravenous glutamine supplementation may affect surgical morbidity. SUMMARY BACKGROUND DATA:: Small-sized randomized trials showed a trend toward a reduction of postoperative infections in surgical patients receiving glutamine. METHODS:: A randomized, multicentre trial was carried out in 428 subjects who were candidates for elective major gastrointestinal surgery. Inclusion criteria were: documented gastrointestinal cancer, weight loss <10% in previous 6 months, and age >18 years. Patients received either intravenous infusion of L-alanine-L-glutamine dipeptide (0.40 g/kg/d; equal to 0.25 g of free glutamine) (Ala-Glu group, n = 212), or no supplementation (control group, n = 216). Glutamine infusion began the day before operation and continued postoperatively for at least 5 days. No postoperative artificial nutrition was allowed unless patients could not adequately eat by day 7. Postoperative morbidity was assessed by independent observers according to a priori definition. RESULTS:: Patients were homogenous for baseline and surgical characteristics. Mean percent of weight loss was 1.4 (2.7) in controls and 1.4 (2.4) in Ala-Glu group. Overall postoperative complication rate was 34.9% (74/212) in Ala-Glu and 32.9% (71/216) in control group (P = 0.65). Infectious morbidity was 19.3% (41/212) in Ala-Glu group and 17.1% (37/216) in controls (P = 0.55). The rate of major complications was 7.5% (16/212) in Ala-Glu group and 7.9% (17/216) in controls (P = 0.90). Mean length of hospitalization was 10.2 days (4.8) in Ala-Glu group versus 9.9 days (3.9) in controls (P = 0.90). The rate of patients requiring postoperative artificial nutrition was 13.2% (28/212) in Ala-Glu group and 12.0% (26/216) in controls (P = 0.71). CONCLUSIONS:: Perioperative glutamine does not affect outcome in well-nourished GI cancer patients. Copyright © 2009 by Lippincott Williams & Wilkins
Gianotti, L., Braga, M., Biffi, R., Bozzetti, F., & Mariani, L. (2009). Perioperative intravenous glutamine supplemetation in major abdominal surgery for cancer: a randomized multicenter trial. ANNALS OF SURGERY, 250(5), 684-690.
| Citazione: | Gianotti, L., Braga, M., Biffi, R., Bozzetti, F., & Mariani, L. (2009). Perioperative intravenous glutamine supplemetation in major abdominal surgery for cancer: a randomized multicenter trial. ANNALS OF SURGERY, 250(5), 684-690. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | No | |
| Titolo: | Perioperative intravenous glutamine supplemetation in major abdominal surgery for cancer: a randomized multicenter trial | |
| Autori: | Gianotti, L; Braga, M; Biffi, R; Bozzetti, F; Mariani, L | |
| Autori: | ||
| Data di pubblicazione: | 2009 | |
| Lingua: | English | |
| Rivista: | ANNALS OF SURGERY | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1097/SLA.0b013e3181bcb28d | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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