Objective: Segmental carotid-femoral pulse-wave velocity (PWV) is a gold standard method for arterial stiffness assessment; recently, a local carotid PWV measurement by ultrasound has been developed. The present study compared the impact of age and established risk factors on carotid and carotid-femoral PWV. Methods: Three hundred and seven volunteers (167 men; age from 15 to 78 years) free of cardiovascular disease, diabetes, antihypertensive and lipid-lowering treatment underwent sequential measurement of carotid and carotidfemoral PWV. Results: In the entire study population, both carotid and carotid-femoral PWV were independently associated mainly with age and blood pressure. In individuals more than 50 years old (N=132, 80 men), carotid-femoral PWV, but not carotid PWV, was also associated with high-density lipoprotein (HDL)-cholesterol and fasting glucose. The annual increase in carotid and carotid-femoral PWV was similar (0.087±0.004 and 0.090±0.005 m/s, respectively; P=0.69). Carotid PWV increased with age more rapidly in women than in men (0.099±0.005 vs. 0.076±0.005 m/s per year, P<0.005), whereas carotid-femoral PWV showed a steeper increase in individuals more than 50 years old than individuals aged 50 years or less (0.150±0.019 vs. 0.088±0.007 m/s per year, P=0.001). Conclusion: In apparently healthy population, both carotid and carotid-femoral PWV were influenced above all by age and blood pressure. Other established cardiovascular risk factors had a limited impact only on carotid-femoral PWV of older individuals. The age-related increase in carotid and carotid-femoral PWV seemed to follow different patterns; increase in carotid PWV showed age-sex interaction, being steeper in women, whereas increase in carotid-femoral PWV was more prominent in older individuals.

Kozakova, M., Morizzo, C., Guarino, D., Federico, G., Miccoli, M., Giannattasio, C., et al. (2015). The impact of age and risk factors on carotid and carotid-femoral pulse wave velocity. JOURNAL OF HYPERTENSION, 33(7), 1446-1451 [10.1097/HJH.0000000000000582].

The impact of age and risk factors on carotid and carotid-femoral pulse wave velocity

GIANNATTASIO, CRISTINA
Penultimo
;
2015

Abstract

Objective: Segmental carotid-femoral pulse-wave velocity (PWV) is a gold standard method for arterial stiffness assessment; recently, a local carotid PWV measurement by ultrasound has been developed. The present study compared the impact of age and established risk factors on carotid and carotid-femoral PWV. Methods: Three hundred and seven volunteers (167 men; age from 15 to 78 years) free of cardiovascular disease, diabetes, antihypertensive and lipid-lowering treatment underwent sequential measurement of carotid and carotidfemoral PWV. Results: In the entire study population, both carotid and carotid-femoral PWV were independently associated mainly with age and blood pressure. In individuals more than 50 years old (N=132, 80 men), carotid-femoral PWV, but not carotid PWV, was also associated with high-density lipoprotein (HDL)-cholesterol and fasting glucose. The annual increase in carotid and carotid-femoral PWV was similar (0.087±0.004 and 0.090±0.005 m/s, respectively; P=0.69). Carotid PWV increased with age more rapidly in women than in men (0.099±0.005 vs. 0.076±0.005 m/s per year, P<0.005), whereas carotid-femoral PWV showed a steeper increase in individuals more than 50 years old than individuals aged 50 years or less (0.150±0.019 vs. 0.088±0.007 m/s per year, P=0.001). Conclusion: In apparently healthy population, both carotid and carotid-femoral PWV were influenced above all by age and blood pressure. Other established cardiovascular risk factors had a limited impact only on carotid-femoral PWV of older individuals. The age-related increase in carotid and carotid-femoral PWV seemed to follow different patterns; increase in carotid PWV showed age-sex interaction, being steeper in women, whereas increase in carotid-femoral PWV was more prominent in older individuals.
Articolo in rivista - Articolo scientifico
Ageing; Arterial stiffness; Risk factors;
risk factors; arotid-femoral pulse-wave velocity (PWV)
English
2015
33
7
1446
1451
none
Kozakova, M., Morizzo, C., Guarino, D., Federico, G., Miccoli, M., Giannattasio, C., et al. (2015). The impact of age and risk factors on carotid and carotid-femoral pulse wave velocity. JOURNAL OF HYPERTENSION, 33(7), 1446-1451 [10.1097/HJH.0000000000000582].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/83987
Citazioni
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 31
Social impact