60)Cu and (64)Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of (60/64)Cu starting from (60/64)Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of (60/64)Ni/(60/64)Cu was developed. Preliminary production yields of (60)Cu and (64)Cu were 400 and 300mCi, respectively. (64)Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2+/-1.3Ci/mumol.

Matarrese, M., Bedeschi, P., Scardaoni, R., Sudati, F., Savi, A., Pepe, A., et al. (2010). Automated production of copper radioisotopes and preparation of high specific activity [(64)Cu]Cu-ATSM for PET studies. APPLIED RADIATION AND ISOTOPES, 68(1), 5-13 [10.1016/j.apradiso.2009.08.010].

Automated production of copper radioisotopes and preparation of high specific activity [(64)Cu]Cu-ATSM for PET studies

TODDE, SERGIO CAMILLO;MESSA, MARIA CRISTINA;FAZIO, FERRUCCIO
2010

Abstract

60)Cu and (64)Cu are useful radioisotopes for positron emission tomography (PET) radiopharmaceuticals and may be used for the preparation of promising agents for diagnosis and radiotherapy. In this study, the production and purification of (60/64)Cu starting from (60/64)Ni using a new automated system, namely Alceo, is described. A dynamic process for electrodeposition and dissolution of (60/64)Ni/(60/64)Cu was developed. Preliminary production yields of (60)Cu and (64)Cu were 400 and 300mCi, respectively. (64)Cu was used to radiolabel the hypoxia detection tracer ATSM with a specific activity of 2.2+/-1.3Ci/mumol.
No
Articolo in rivista - Articolo scientifico
Scientifica
Alceo; Solid target; 60Cu; Radionuclide production; PET
English
Matarrese, M., Bedeschi, P., Scardaoni, R., Sudati, F., Savi, A., Pepe, A., et al. (2010). Automated production of copper radioisotopes and preparation of high specific activity [(64)Cu]Cu-ATSM for PET studies. APPLIED RADIATION AND ISOTOPES, 68(1), 5-13 [10.1016/j.apradiso.2009.08.010].
Matarrese, M; Bedeschi, P; Scardaoni, R; Sudati, F; Savi, A; Pepe, A; Masiello, V; Todde, S; Gianolli, L; Messa, M; Fazio, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/8388
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