AIM: Anti-androgenic hormonal therapy in prostate cancer patients with concomitant meningioma may result in tumor growth and development of neurological symptoms. Positron emission tomography/computed tomography (PET/CT) with [(11)C]choline is used for restaging prostate cancer patients with biochemical failure. In vitro and in vivo data support altered choline metabolism in meningiomas. METHODS: During a retrospective study in prostate cancer patients with biochemical failure referred to our institution between November 2004 and Ja-nuary 2007, encephalic focal uptake of [(11)C]choline was incidentally noted in 4 patients, 2 of which had been taking luteinizing hormone-releasing hormone analogs. RESULTS: Subsequent to the incidental finding, one patient underwent surgical removal of the meningioma; strict neuroradiological follow-up was planned for the 3 other patients. CONCLUSIONS: We suggest that in prostate cancer patients candidate for anti-androgenic therapy the whole body [(11)C]choline PET/CT scan should include the whole skull to check for the possible presence of meningiomas. This could help to identify patients at risk for the development of neurological symptoms during anti-androgenic therapy and help the referring urologist in the clinical management of these patients.
Fallanca, F., Giovacchini, G., Picchio, M., Bettinarda, V., Messa, M.C., & Fazio, F. (2009). Incidental detection by [(11)C]choline PET/CT of meningiomas in prostate cancer patients. THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 53, 417-421.
Citazione: | Fallanca, F., Giovacchini, G., Picchio, M., Bettinarda, V., Messa, M.C., & Fazio, F. (2009). Incidental detection by [(11)C]choline PET/CT of meningiomas in prostate cancer patients. THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 53, 417-421. | |
Tipo: | Articolo in rivista - Articolo scientifico | |
Carattere della pubblicazione: | Scientifica | |
Presenza di un coautore afferente ad Istituzioni straniere: | No | |
Titolo: | Incidental detection by [(11)C]choline PET/CT of meningiomas in prostate cancer patients | |
Autori: | Fallanca, F; Giovacchini, G; Picchio, M; Bettinarda, V; Messa, MC; Fazio, F | |
Autori: | ||
Data di pubblicazione: | 2009 | |
Lingua: | English | |
Rivista: | THE QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | |
Appare nelle tipologie: | 01 - Articolo su rivista |