Aims: To assess the effect of different combinations of potassium and calcium concentrations on QT interval in the dialysis bath in uraemic patients. Methods and results: Sixteen haemodialysis (HD) patients underwent a 24 h Holter recording before and during HD sessions with six randomized combinations of electrolytes concentrations of the dialysis bath (K<sup>+</sup>, 2 and 3 mmol/L; Ca<sup>2+</sup>, 1.25, 1.5, and 1.75 mmol/L). The effect of different dialysis baths on QT interval was significant (P &lt; 0.05). The longest mean QTc was observed with the lowest K<sup>+</sup> (2 mmol/L) and Ca<sup>2+</sup> concentrations (1.25 mmol/L), whereas the shortest mean QTc was observed with the highest K<sup>+</sup> (3 mmol/L) and Ca<sup>2+</sup> concentrations (1.75 mmol/L). QTc was &gt;440 ms in 9 of 16 patients (56%) at the lowest Ca <sup>2+</sup> and K<sup>+</sup> concentrations, and in 3 of 16 patients (18%) at the highest electrolytes level. Changes in QTc during the HD sessions were inversely correlated with that in total Ca and Ca<sup>2+</sup> plasma concentrations (P &lt; 0.0001). Conclusion: Changes in ventricular repolarization duration associated with HD largely depend on the concentrations of Ca<sup>2+</sup> and K<sup>+</sup> in the dialysis bath. These findings may have important implications for the choice of the electrolytes concentration of the dialysis bath during the HD session. © The Author 2008.

Genovesi, S., Dossi, C., Viganò, M., Galbiati, E., Prolo, F., Stella, A., et al. (2008). Electrolyte concentration during haemodialysis and QT interval prolongation in uremic patients. EUROPACE, 10(6), 771-777 [10.1093/europace/eun028].

Electrolyte concentration during haemodialysis and QT interval prolongation in uremic patients

GENOVESI, SIMONETTA CARLA;STELLA, ANDREA;
2008

Abstract

Aims: To assess the effect of different combinations of potassium and calcium concentrations on QT interval in the dialysis bath in uraemic patients. Methods and results: Sixteen haemodialysis (HD) patients underwent a 24 h Holter recording before and during HD sessions with six randomized combinations of electrolytes concentrations of the dialysis bath (K+, 2 and 3 mmol/L; Ca2+, 1.25, 1.5, and 1.75 mmol/L). The effect of different dialysis baths on QT interval was significant (P < 0.05). The longest mean QTc was observed with the lowest K+ (2 mmol/L) and Ca2+ concentrations (1.25 mmol/L), whereas the shortest mean QTc was observed with the highest K+ (3 mmol/L) and Ca2+ concentrations (1.75 mmol/L). QTc was >440 ms in 9 of 16 patients (56%) at the lowest Ca 2+ and K+ concentrations, and in 3 of 16 patients (18%) at the highest electrolytes level. Changes in QTc during the HD sessions were inversely correlated with that in total Ca and Ca2+ plasma concentrations (P < 0.0001). Conclusion: Changes in ventricular repolarization duration associated with HD largely depend on the concentrations of Ca2+ and K+ in the dialysis bath. These findings may have important implications for the choice of the electrolytes concentration of the dialysis bath during the HD session. © The Author 2008.
Articolo in rivista - Articolo scientifico
QT interval, Haemodialysis, potassium, calcium
English
771
777
Genovesi, S., Dossi, C., Viganò, M., Galbiati, E., Prolo, F., Stella, A., et al. (2008). Electrolyte concentration during haemodialysis and QT interval prolongation in uremic patients. EUROPACE, 10(6), 771-777 [10.1093/europace/eun028].
Genovesi, S; Dossi, C; Viganò, M; Galbiati, E; Prolo, F; Stella, A; Stramba Badiale, M
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/8334
Citazioni
  • Scopus 91
  • ???jsp.display-item.citation.isi??? 89
Social impact