Sleep disorders are frequently reported in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization. Although changes in sleep organization are a hallmark of the normal aging processes, sleep macro-and micro-architectural alterations are more evident in patients affected by AD. Degeneration of neural pathways regulating sleep-wake patterns and sleep architecture may contribute to sleep alterations. In return, several recent studies suggested that common sleep disorders may precede clinical symptoms of dementia and represent risk factors for cognitive decline, through impairment of sleep-dependent memory consolidation processes. Thus, a close relationship between sleep disorders and AD has been largely hypothesized. Here, sleep alterations in AD and its pre-dementia stage, mild cognitive impairment, and their complex interactions are reviewed.

Villa, C., Ferini Strambi, L., Combi, R. (2015). The synergistic relationship between Alzheimer's disease and sleep disorders: An update. JOURNAL OF ALZHEIMER'S DISEASE, 46(3), 571-580 [10.3233/JAD-150138].

The synergistic relationship between Alzheimer's disease and sleep disorders: An update

VILLA, CHIARA
Primo
;
COMBI, ROMINA
Ultimo
2015

Abstract

Sleep disorders are frequently reported in Alzheimer's disease (AD), with a significant impact on patients and caregivers and a major risk factor for early institutionalization. Although changes in sleep organization are a hallmark of the normal aging processes, sleep macro-and micro-architectural alterations are more evident in patients affected by AD. Degeneration of neural pathways regulating sleep-wake patterns and sleep architecture may contribute to sleep alterations. In return, several recent studies suggested that common sleep disorders may precede clinical symptoms of dementia and represent risk factors for cognitive decline, through impairment of sleep-dependent memory consolidation processes. Thus, a close relationship between sleep disorders and AD has been largely hypothesized. Here, sleep alterations in AD and its pre-dementia stage, mild cognitive impairment, and their complex interactions are reviewed.
Articolo in rivista - Review Essay
Alzheimer’s disease; amyloid-β; mild cognitive impairment; sleep disorders
English
2015
46
3
571
580
none
Villa, C., Ferini Strambi, L., Combi, R. (2015). The synergistic relationship between Alzheimer's disease and sleep disorders: An update. JOURNAL OF ALZHEIMER'S DISEASE, 46(3), 571-580 [10.3233/JAD-150138].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/81582
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