Polyurethene (PU) catheters were coated with 3-(trimethoxysilyl)-propyldimethyloctadecylammonium chloride (QAS) by means of a multistep process which involved a vapor phase plasma-induced graft-polymerization of acrylic acid (AAc). The AAc coating, whose stability in aqueous media was assessed by immersion in Phospate Buffer Saline (PBS), was characterized by means of Attenuated Total Reflectance Fourier Transform Infrared (ATR/FTIR) spectroscopy. Moreover, the COOH surface density was evaluated by a colorimetric assay with Methylene Blue. Carrying a negative charge at neutral pH, AAc coatings were proficient in positively charged molecules (like QAS) adsorption. ATR/FTIR spectroscopy and a colorimetric assay with Bromophenol Blue allowed us to verify the presence and the uniformity of the QAS coating on the PU catheters and the positive effect of the AAc graft-polymerization on the QAS adsorption. Morphological characterization of the QAS-modified catheters was performed by means of Atomic Force Microscopy (AFM). QAS-coated catheters displayed in vitro antimicrobial activity against Gram-negative Escherichia coli bacterial cells.

Zanini, S., Polissi, A., Maccagni, E., Dell'Orto, E., Liberatore, C., Riccardi, C. (2015). Development of antibacterial quaternary ammonium silane coatings on polyurethane catheters. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 451, 78-84 [10.1016/j.jcis.2015.04.007].

Development of antibacterial quaternary ammonium silane coatings on polyurethane catheters

ZANINI, STEFANO;POLISSI, ALESSANDRA;MACCAGNI, ELISA ANNA;DELL'ORTO, ELISA CAMILLA;RICCARDI, CLAUDIA
2015

Abstract

Polyurethene (PU) catheters were coated with 3-(trimethoxysilyl)-propyldimethyloctadecylammonium chloride (QAS) by means of a multistep process which involved a vapor phase plasma-induced graft-polymerization of acrylic acid (AAc). The AAc coating, whose stability in aqueous media was assessed by immersion in Phospate Buffer Saline (PBS), was characterized by means of Attenuated Total Reflectance Fourier Transform Infrared (ATR/FTIR) spectroscopy. Moreover, the COOH surface density was evaluated by a colorimetric assay with Methylene Blue. Carrying a negative charge at neutral pH, AAc coatings were proficient in positively charged molecules (like QAS) adsorption. ATR/FTIR spectroscopy and a colorimetric assay with Bromophenol Blue allowed us to verify the presence and the uniformity of the QAS coating on the PU catheters and the positive effect of the AAc graft-polymerization on the QAS adsorption. Morphological characterization of the QAS-modified catheters was performed by means of Atomic Force Microscopy (AFM). QAS-coated catheters displayed in vitro antimicrobial activity against Gram-negative Escherichia coli bacterial cells.
Articolo in rivista - Articolo scientifico
Acrylic acid; AFM; ATR/FTIR; Escherichia coli; Plasma-induced graft-polymerization; Quaternary ammonium silane;
Plasma-induced graft-polymerization; Acrylic acid; ATR/FTIR; AFM; Quaternary ammonium silane; Escherichia coli
English
2015
451
78
84
reserved
Zanini, S., Polissi, A., Maccagni, E., Dell'Orto, E., Liberatore, C., Riccardi, C. (2015). Development of antibacterial quaternary ammonium silane coatings on polyurethane catheters. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 451, 78-84 [10.1016/j.jcis.2015.04.007].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/80931
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