Neurological soft signs (NSS) are semeiotic anomalies not assessed by the standard neurological examination, primarily developed in psychiatric settings and recently proposed as potential markers of minor brain circuit alterations, especially the cerebellar-thalamic-prefrontal network. Primary headache patients present with normal neurological examination and frequent psychiatric comorbidity. Aim of this exploratory study consisted in assessing NSS in 20 episodic frequent migraine (MH) and in 10 tension-type headache (ETTH) outpatients compared to 30 matched healthy controls. NSS were assessed by the Heidelberg scale; clinical characteristics and brain MRI were additionally obtained in all patients. NSS were increased by ~70 and ~90% in ETTH and MH, respectively, with respect to controls (p< 0.001) and the difference remained significant even after controlling for age and education. Headache type and characteristics did not influence NSS presentation, while headache patients with white matter hyperintensities (WMH) at brain MRI had higher NSS scores compared both to normal controls and patients without WMH. NSS identify a subset of primary headache patients sharing the same comorbidities or minimal brain anomalies, suggesting that tailored prophylactic options might apply.

Tremolizzo, L., Ferrario, S., Pellegrini, A., Fumagalli, L., Ferrarese, C., Appollonio, I. (2015). Neurological soft signs in primary headache patients. NEUROSCIENCE LETTERS, 595, 41-44 [10.1016/j.neulet.2015.04.007].

Neurological soft signs in primary headache patients

TREMOLIZZO, LUCIO
Primo
;
FUMAGALLI, LORENZO;FERRARESE, CARLO
Penultimo
;
APPOLLONIO, ILDEBRANDO
Ultimo
2015

Abstract

Neurological soft signs (NSS) are semeiotic anomalies not assessed by the standard neurological examination, primarily developed in psychiatric settings and recently proposed as potential markers of minor brain circuit alterations, especially the cerebellar-thalamic-prefrontal network. Primary headache patients present with normal neurological examination and frequent psychiatric comorbidity. Aim of this exploratory study consisted in assessing NSS in 20 episodic frequent migraine (MH) and in 10 tension-type headache (ETTH) outpatients compared to 30 matched healthy controls. NSS were assessed by the Heidelberg scale; clinical characteristics and brain MRI were additionally obtained in all patients. NSS were increased by ~70 and ~90% in ETTH and MH, respectively, with respect to controls (p< 0.001) and the difference remained significant even after controlling for age and education. Headache type and characteristics did not influence NSS presentation, while headache patients with white matter hyperintensities (WMH) at brain MRI had higher NSS scores compared both to normal controls and patients without WMH. NSS identify a subset of primary headache patients sharing the same comorbidities or minimal brain anomalies, suggesting that tailored prophylactic options might apply.
Articolo in rivista - Articolo scientifico
comorbidity; endophenotypes; episodic frequent tension-type headache; migraine; neurological soft signs; white matter hyperintensities
English
41
44
4
Tremolizzo, L., Ferrario, S., Pellegrini, A., Fumagalli, L., Ferrarese, C., Appollonio, I. (2015). Neurological soft signs in primary headache patients. NEUROSCIENCE LETTERS, 595, 41-44 [10.1016/j.neulet.2015.04.007].
Tremolizzo, L; Ferrario, S; Pellegrini, A; Fumagalli, L; Ferrarese, C; Appollonio, I
File in questo prodotto:
File Dimensione Formato  
2015. Neurosci Lett - NSS headache.pdf

Solo gestori archivio

Descrizione: articolo
Dimensione 443.46 kB
Formato Adobe PDF
443.46 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/80624
Citazioni
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
Social impact