The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at telomeres. Since the vast majority of the cells in mammals are non-proliferating, how do they age? Are telomeres involved? Also oncogene activation causes cellular senescence due to altered DNA replication and DDR activation in particular at the telomeres. Is there a common mechanism shared among apparently distinct types of cellular senescence? And what is the role of telomeric DNA damage? © 2014 The Authors Elsevier Ltd.

Rossiello, F., Herbig, U., Longhese, M., Fumagalli, M., d'Adda di Fagagna, F. (2014). Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. CURRENT OPINION IN GENETICS & DEVELOPMENT, 26, 89-95 [10.1016/j.gde.2014.06.009].

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

LONGHESE, MARIA PIA;
2014

Abstract

The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR persistence at telomeres. Since the vast majority of the cells in mammals are non-proliferating, how do they age? Are telomeres involved? Also oncogene activation causes cellular senescence due to altered DNA replication and DDR activation in particular at the telomeres. Is there a common mechanism shared among apparently distinct types of cellular senescence? And what is the role of telomeric DNA damage? © 2014 The Authors Elsevier Ltd.
Articolo in rivista - Articolo scientifico
Genetics; Developmental Biology
English
2014
26
89
95
none
Rossiello, F., Herbig, U., Longhese, M., Fumagalli, M., d'Adda di Fagagna, F. (2014). Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing. CURRENT OPINION IN GENETICS & DEVELOPMENT, 26, 89-95 [10.1016/j.gde.2014.06.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/80587
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