IRIS – Institutional Research Information System
IRIS è il sistema di gestione della ricerca dell’Università degli Studi di Milano-Bicocca.Il repository BOA è il modulo del sistema dedicato alla raccolta e alla disseminazione della produzione scientifica di Ateneo. Le pubblicazioni sono ricercabili per parola chiave attraverso il box nella barra orizzontale in alto oppure, mediante il pulsante Sfoglia, per "Afferenza", "Autore", "Titolo", "Tipologia" o "Settore scientifico-disciplinare".
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EnglishPompilidotoxins (PMTXs, alpha and beta) are small peptides consisting of 13 amino acids purified from the venom of the solitary wasps Anoplius samariensis (alpha-PMTX) and Batozonellus maculifrons (beta-PMTX). They are known to facilitate synaptic transmission in the lobster neuromuscular junction, and to slow sodium channel inactivation. By using beta-PMTX, alpha-PMTX and four synthetic analogs with amino acid changes, we conducted a thorough study of the effects of PMTXs on sodium current inactivation in seven mammalian voltage-gated sodium channel (VGSC) isoforms and one insect VGSC (DmNa(v)1). By evaluating three components of which the inactivating current is composed (fast, slow and steady-state components), we could distinguish three distinct groups of PMTX effects. The first group concerned the insect and Na(v)1.6 channels, which showed a large increase in the steady-state current component without any increase in the slow component. Moreover, the dose-dependent increase in this steady-state component was correlated with the dose-dependent decrease in the fast component. A second group of effects concerned the Na(v)1.1, Na(v)1.2, Na(v)1.3 and Na(v)1.7 isoforms, which responded with a large increase in the slow component, and showed only a small steady-state component. As with the first group of effects, the slow component was dose-dependent and correlated with the decrease in the fast component. Finally, a third group of effects concerned Na(v)1.4 and Na(v)1.5, which did not show any change in the slow or steady-state component. These data shed light on the complex and intriguing behavior of VGSCs in response to PMTXs, helping us to better understand the molecular determinants explaining isoform-specific effects.
Schiavon, E., Stevens, M., Zaharenko, A., Konno, K., Tytgat, J., & Wanke, E. (2010). Voltage-gated Sodium Channels Isoform-specific Effects of Pompilidotoxins. THE FEBS JOURNAL, 277(4), 918-930 [10.1111/j.1742-4658.2009.07533.x].
| Citazione: | Schiavon, E., Stevens, M., Zaharenko, A., Konno, K., Tytgat, J., & Wanke, E. (2010). Voltage-gated Sodium Channels Isoform-specific Effects of Pompilidotoxins. THE FEBS JOURNAL, 277(4), 918-930 [10.1111/j.1742-4658.2009.07533.x]. | |
| Tipo: | Articolo in rivista - Articolo scientifico | |
| Carattere della pubblicazione: | Scientifica | |
| Presenza di un coautore afferente ad Istituzioni straniere: | Si | |
| Titolo: | Voltage-gated Sodium Channels Isoform-specific Effects of Pompilidotoxins | |
| Autori: | Schiavon, E; Stevens, M; Zaharenko, A; Konno, K; Tytgat, J; Wanke, E | |
| Autori: | ||
| Data di pubblicazione: | 2010 | |
| Lingua: | English | |
| Rivista: | THE FEBS JOURNAL | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/j.1742-4658.2009.07533.x | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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