Animal evidence suggests an association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and adverse pregnancy outcomes. Epidemiologic studies report inconsistent results, but are limited by narrow range of exposure, small sample size, and lack of a biologic measure of highest lifetime exposure. On July 10, 1976, a chemical explosion in Seveso, Italy resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women's Health Study (SWHS), a retrospective cohort of TCDD exposure and reproductive health. Individual-level TCDD was measured in serum collected soon after the explosion. After 20years of follow-up, we found no association between maternal TCDD in 1976 serum or estimated at pregnancy and spontaneous abortion (SAB), fetal growth, or gestational length. Here, we present an updated analysis of TCDD exposure and adverse pregnancy outcomes from a subsequent follow-up of the SWHS cohort in 2008-2009. SWHS women had 1211 post-explosion pregnancies through the 2008-2009 follow-up. We found no association between TCDD estimated at pregnancy and SAB, fetal growth, or gestational length. However, we found a non-significant inverse association between maternal 1976 serum TCDD and birthweight (adjusted β=-22.8, 95% CI: -80.1, 34.6). The association was stronger among first post-explosion births, but remained non-significant (adjusted β=-47.7, 95% CI: -107.3, 11.9). SWHS is the first study to be able to consider two potentially relevant measures of TCDD exposure: highest lifetime dose and in utero. Our results, although non-significant, suggest that highest dose may be more relevant in epidemiologic studies of TCDD and pregnancy outcomes.

Wesselink, A., Warner, M., Samuels, S., Parigi, A., Brambilla, P., Mocarelli, P., et al. (2014). Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. ENVIRONMENT INTERNATIONAL, 63, 143-148 [10.1016/j.envint.2013.11.005].

Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso

BRAMBILLA, PAOLO;MOCARELLI, PAOLO
Penultimo
;
2014

Abstract

Animal evidence suggests an association between exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and adverse pregnancy outcomes. Epidemiologic studies report inconsistent results, but are limited by narrow range of exposure, small sample size, and lack of a biologic measure of highest lifetime exposure. On July 10, 1976, a chemical explosion in Seveso, Italy resulted in the highest known residential exposure to TCDD. In 1996, we initiated the Seveso Women's Health Study (SWHS), a retrospective cohort of TCDD exposure and reproductive health. Individual-level TCDD was measured in serum collected soon after the explosion. After 20years of follow-up, we found no association between maternal TCDD in 1976 serum or estimated at pregnancy and spontaneous abortion (SAB), fetal growth, or gestational length. Here, we present an updated analysis of TCDD exposure and adverse pregnancy outcomes from a subsequent follow-up of the SWHS cohort in 2008-2009. SWHS women had 1211 post-explosion pregnancies through the 2008-2009 follow-up. We found no association between TCDD estimated at pregnancy and SAB, fetal growth, or gestational length. However, we found a non-significant inverse association between maternal 1976 serum TCDD and birthweight (adjusted β=-22.8, 95% CI: -80.1, 34.6). The association was stronger among first post-explosion births, but remained non-significant (adjusted β=-47.7, 95% CI: -107.3, 11.9). SWHS is the first study to be able to consider two potentially relevant measures of TCDD exposure: highest lifetime dose and in utero. Our results, although non-significant, suggest that highest dose may be more relevant in epidemiologic studies of TCDD and pregnancy outcomes.
Articolo in rivista - Articolo scientifico
IQR; polychlorinated dibenzodioxin; Animals; Women's Health; Humans; Retrospective Studies; SWHS; Italy; Maternal Exposure; Tetrachlorodibenzodioxin; Birthweight; parts-per-trillion; Adult; Seveso Women's Health Study; PCDF; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TEQ; PCDD; PCB; interquartile range; Pregnancy Outcome; SAB; Fetal growth; toxic equivalent; TCDD; Preterm; ppt; small-for-gestational age; OR; Pregnancy; spontaneous abortion; Seveso; Pregnancy outcomes; odds ratio; Follow-Up Studies; polychlorinated biphenyl; polychlorinated dibenzofuran; Female; SGA; Dioxin
English
2014
63
143
148
none
Wesselink, A., Warner, M., Samuels, S., Parigi, A., Brambilla, P., Mocarelli, P., et al. (2014). Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. ENVIRONMENT INTERNATIONAL, 63, 143-148 [10.1016/j.envint.2013.11.005].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/79480
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