3-Deoxy-D-threopentofuranose 5-phosphate, a substrate of arabinose 5-phosphate isomerase, has been synthesised starting from D-arabinose. Selective protection of the hydroxyl groups at C-1, C-2 and C-5 allowed to deoxygenate position 3 by conversion into a thiocarbamate and radical reduction. Deprotection and phosphorylation of the primary hydroxyl group, and final deprotection of the other hydroxyl groups afforded the desired compound
Airoldi, C., Merlo, S., & Nicotra, F. (2010). Synthesis of 3-Deoxy-D-threopentofuranose 5-Phosphate, a Substrate of Arabinose 5-Phosphate Isomerase. JOURNAL OF CARBOHYDRATE CHEMISTRY, 29, 30-38.
Citazione: | Airoldi, C., Merlo, S., & Nicotra, F. (2010). Synthesis of 3-Deoxy-D-threopentofuranose 5-Phosphate, a Substrate of Arabinose 5-Phosphate Isomerase. JOURNAL OF CARBOHYDRATE CHEMISTRY, 29, 30-38. |
Tipo: | Articolo in rivista - Articolo scientifico |
Carattere della pubblicazione: | Scientifica |
Titolo: | Synthesis of 3-Deoxy-D-threopentofuranose 5-Phosphate, a Substrate of Arabinose 5-Phosphate Isomerase |
Autori: | Airoldi, C; Merlo, S; Nicotra, F |
Autori: | |
Data di pubblicazione: | gen-2010 |
Lingua: | English |
Rivista: | JOURNAL OF CARBOHYDRATE CHEMISTRY |
Appare nelle tipologie: | 01 - Articolo su rivista |