Alemtuzumab has been shown to be effective in poor-prognosis chronic lymphocytic leukemia (CLL); treatment, however, has been associated with significant toxicity. With the aim of seeking better tolerability, we treated 39 patients with fludarabine-refractory CLL subcutaneous alemtuzumab 10 mg three times a week, for 18 weeks. In 18 randomly selected patients, after obtaining lymphocyte count reduction by 1 Log, the antibody was administered once weekly at the dose of 30 mg. Overall response rate was 44%, including 8% complete remissions. Median overall survival and progression free survival were 29.1 and 10.3 months, respectively. Treatment was well tolerated, severe non-CMV infection occurred in 7% of the patients. CMV reactivation was detected in 27% of the patients, with only one case of CMV disease. No deaths occurred during therapy. In conclusion, low-dose alemtuzumab shows a promising safety profile coupled with satisfactory effectiveness in this category of poor prognosis CLL patients. © 2012 Informa UK, Ltd.
Gritti, G., Reda, G., Maura, F., Piciocchi, A., Baldini, L., Molica, S., et al. (2012). Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA, 53(3), 424-429 [10.3109/10428194.2011.623258].
|Citazione:||Gritti, G., Reda, G., Maura, F., Piciocchi, A., Baldini, L., Molica, S., et al. (2012). Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia. LEUKEMIA & LYMPHOMA, 53(3), 424-429 [10.3109/10428194.2011.623258].|
|Tipo:||Articolo in rivista - Articolo scientifico|
|Carattere della pubblicazione:||Scientifica|
|Presenza di un coautore afferente ad Istituzioni straniere:||No|
|Titolo:||Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia|
|Autori:||Gritti, G; Reda, G; Maura, F; Piciocchi, A; Baldini, L; Molica, S; Neri, A; Cortelezzi, A|
GRITTI, GIUSEPPE (Primo)
|Data di pubblicazione:||2012|
|Rivista:||LEUKEMIA & LYMPHOMA|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3109/10428194.2011.623258|
|Appare nelle tipologie:||01 - Articolo su rivista|