Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed

Vergani, C., Sampietro, M., Caputo, L., Tagliabue, J., Casatta, A., Meregalli, M., et al. (2001). Cognitive disorders in the elderly. Genetic and epigenetic aspects. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 7, 429-434 [10.1016/S0167-4943(01)00170-4].

Cognitive disorders in the elderly. Genetic and epigenetic aspects

ANNONI, GIORGIO
2001

Abstract

Alzheimer's disease (AD) represents the most prevalent manifestation of the cognitive disorders in the elderly. The dramatic nature and the economic burden of the disease make AD a worl-wide problem. This paper reviews the genetic factors which explain the pathogenesis of AD, i.e., mutations of the genes encoding the amyloid precursor protein (APP), presenilin 1 (PS-1) and 2 (PS-2). Moreover, the polymorphism of the ApoE gene and the mutations of the hemochromatosis gene (HFE) are discussed. HFE mutations may anticipate the clinical manifestation of AD. The epigenetic factors related to AD are also discussed
Articolo in rivista - Articolo scientifico
Alzheimer's disease; iron metabolism; hemochromatosis; HFE gene; ApoE
English
2001
7
429
434
none
Vergani, C., Sampietro, M., Caputo, L., Tagliabue, J., Casatta, A., Meregalli, M., et al. (2001). Cognitive disorders in the elderly. Genetic and epigenetic aspects. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 7, 429-434 [10.1016/S0167-4943(01)00170-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/764
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