We present the results of bronchoalveolar lavage (BAL) performed in three patients with severe influenza A/H1N1 pneumonia complicated by acute respiratory distress syndrome (ARDS). Light microscopy analysis of BAL cytocentrifugates showed the presence of characteristic large, mononuclear, plasmoblastic/plasmocytoid-like cells never described before. Via transmission electron microscopy, these cells were classified as atypical type II pneumocytes and some of them showed cytoplasmic vesicles and inclusions. We concluded that plasmoblastic/plasmocytoid-like type II pneumocytes might represent a morphologic marker of A/H1N1 influenza virus infection as well as reparative cellular activation after diffuse alveolar damage.

Faverio, P., Aliberti, S., Ezekiel, C., Messinesi, G., Brenna, A., Pesci, A. (2014). Influenza A/H1N1 severe pneumonia: Novel morphocytological findings in bronchoalveolar lavage. INTERDISCIPLINARY PERSPECTIVES ON INFECTIOUS DISEASES, 2014, 470825 [10.1155/2014/470825].

Influenza A/H1N1 severe pneumonia: Novel morphocytological findings in bronchoalveolar lavage

FAVERIO, PAOLA
Primo
;
ALIBERTI, STEFANO
Secondo
;
MESSINESI, GRAZIA;PESCI, ALBERTO
Ultimo
2014

Abstract

We present the results of bronchoalveolar lavage (BAL) performed in three patients with severe influenza A/H1N1 pneumonia complicated by acute respiratory distress syndrome (ARDS). Light microscopy analysis of BAL cytocentrifugates showed the presence of characteristic large, mononuclear, plasmoblastic/plasmocytoid-like cells never described before. Via transmission electron microscopy, these cells were classified as atypical type II pneumocytes and some of them showed cytoplasmic vesicles and inclusions. We concluded that plasmoblastic/plasmocytoid-like type II pneumocytes might represent a morphologic marker of A/H1N1 influenza virus infection as well as reparative cellular activation after diffuse alveolar damage.
Articolo in rivista - Articolo scientifico
Infectious Diseases; Microbiology (medical); Microbiology; Parasitology; Virology; pneumonia; influenza
English
470825
Faverio, P., Aliberti, S., Ezekiel, C., Messinesi, G., Brenna, A., Pesci, A. (2014). Influenza A/H1N1 severe pneumonia: Novel morphocytological findings in bronchoalveolar lavage. INTERDISCIPLINARY PERSPECTIVES ON INFECTIOUS DISEASES, 2014, 470825 [10.1155/2014/470825].
Faverio, P; Aliberti, S; Ezekiel, C; Messinesi, G; Brenna, A; Pesci, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/76164
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