Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-IP genes affected plasma levels of ACT or IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype show-ed the highest levels of plasma ACT or IL-1 beta, respectively. The concomitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease

Licastro, F., Pedrini, S., Ferri, C., Casadei, V., Govoni, M., Pession, A., et al. (2000). Gene Polymorphism affecting Alpha-1-Antichymotrypsin and interleukin 1 Plasma Levels increases Alzheimer Disease Risk. ANNALS OF NEUROLOGY, 48(3), 388-391 [10.1002/1531-8249(200009)48:3<388::AID-ANA16>3.0.CO;2-G].

Gene Polymorphism affecting Alpha-1-Antichymotrypsin and interleukin 1 Plasma Levels increases Alzheimer Disease Risk

ANNONI, GIORGIO;
2000

Abstract

Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-IP genes affected plasma levels of ACT or IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype show-ed the highest levels of plasma ACT or IL-1 beta, respectively. The concomitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease
Articolo in rivista - Articolo scientifico
APOLIPOPROTEIN-E; BRAIN; ALPHA(1)-ANTICHYMOTRYPSIN; ALLELE; ALPHA; APOE
English
2000
48
3
388
391
none
Licastro, F., Pedrini, S., Ferri, C., Casadei, V., Govoni, M., Pession, A., et al. (2000). Gene Polymorphism affecting Alpha-1-Antichymotrypsin and interleukin 1 Plasma Levels increases Alzheimer Disease Risk. ANNALS OF NEUROLOGY, 48(3), 388-391 [10.1002/1531-8249(200009)48:3<388::AID-ANA16>3.0.CO;2-G].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/759
Citazioni
  • Scopus 128
  • ???jsp.display-item.citation.isi??? 117
Social impact