Plasma levels of al-antichymotrypsin (ACT) and interleukin-1 beta (IL-1 beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-IP genes affected plasma levels of ACT or IL-1 beta, and AD patients with the ACT T,T or IL-1 beta T,T genotype show-ed the highest levels of plasma ACT or IL-1 beta, respectively. The concomitant presence of the ACT T,T and IL-1 beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease
Plasma levels of α1-antichymotrypsin (ACT) and interleukin-1β (IL-1β) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1β genes affected plasma levels of ACT or IL-1β, and AD patients with the ACT T,T or IL-1β T,T genotype showed the highest levels of plasma ACT or IL-1β, respectively. The concomitant presence of the ACT T,T and IL-1β T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
Licastro, F., Pedrini, S., Ferri, C., Casadei, V., Govoni, M., Pession, A., et al. (2000). Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk. ANNALS OF NEUROLOGY, 48(3), 388-391 [10.1002/1531-8249(200009)48:3<388::AID-ANA16>3.0.CO;2-G].
Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk
ANNONI, GIORGIO;
2000
Abstract
Plasma levels of α1-antichymotrypsin (ACT) and interleukin-1β (IL-1β) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1β genes affected plasma levels of ACT or IL-1β, and AD patients with the ACT T,T or IL-1β T,T genotype showed the highest levels of plasma ACT or IL-1β, respectively. The concomitant presence of the ACT T,T and IL-1β T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.
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