By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a 15N-edited HSQC NMR experiment the ligand-Ras binding interface

Palmioli, A., Sacco, E., Abraham, S., Thomas, C., DI DOMIZIO, A., DE GIOIA, L., et al. (2009). First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(15), 4217-4222 [10.1016/j.bmcl.2009.05.107].

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand

PALMIOLI, ALESSANDRO;SACCO, ELENA;DI DOMIZIO, ALESSANDRO;DE GIOIA, LUCA;VANONI, MARCO ERCOLE;PERI, FRANCESCO
2009

Abstract

By combining in the same molecule Ras-interacting aromatic moieties and a sugar, we prepared a water-soluble Ras ligand that binds Ras and inhibits guanine nucleotide exchange. With this compound it was possible to determine experimentally by a 15N-edited HSQC NMR experiment the ligand-Ras binding interface
Articolo in rivista - Articolo scientifico
Scientifica
Ras protein, Sugars, Synthesis, Anticancer agents, NMR, Molecular modeling
English
4217
4222
Palmioli, A., Sacco, E., Abraham, S., Thomas, C., DI DOMIZIO, A., DE GIOIA, L., et al. (2009). First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 19(15), 4217-4222 [10.1016/j.bmcl.2009.05.107].
Palmioli, A; Sacco, E; Abraham, S; Thomas, C; DI DOMIZIO, A; DE GIOIA, L; Gaponenko, V; Vanoni, M; Peri, F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/7488
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