Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.

Brubaker, S., Bonham, K., Zanoni, I., Kagan, J. (2015). Innate Immune Pattern Recognition: A Cell Biological Perspective. ANNUAL REVIEW OF IMMUNOLOGY, 33, 257-290 [10.1146/annurev-immunol-032414-112240].

Innate Immune Pattern Recognition: A Cell Biological Perspective

ZANONI, IVAN
Penultimo
;
2015

Abstract

Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.
Articolo in rivista - Review Essay
Innate immunity
English
2015
33
257
290
reserved
Brubaker, S., Bonham, K., Zanoni, I., Kagan, J. (2015). Innate Immune Pattern Recognition: A Cell Biological Perspective. ANNUAL REVIEW OF IMMUNOLOGY, 33, 257-290 [10.1146/annurev-immunol-032414-112240].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10281/68570
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