Background: Mild, long-term non-compliance with immunosuppressive treatment after organ transplantation is common, and can result in early mortality. One possible source of non-compliance is the belief that the treatment is ineffective or unnecessary. This study investigates patients perception of the efficacy of their immunosuppressive treatment in a sample of heart transplant patients. Methods: A questionnaire was given to 67 heart transplant recipients. The first part of the questionnaire addressed health-related behavior and attitude toward the immunosuppressive medication, using self-report questions. In the second part of the questionnaire, participants evaluated the perceived risk of rejection associated with non-compliant behaviors described in 8 scenarios. Results: The data from the self-report questions showed a mild level of behavioral non-compliance, increasing over time, and a mild level of medication non-compliance. One third of the medication non-compliant patients chose the inefficacy or non-necessity of the treatment as a main cause of non-compliance. The second part of the questionnaire showed that subjective perceived efficacy of the immunosuppressive treatment decreased over time. Conclusions: Medication non-compliance is fostered by many factors. One of these is the belief that the treatment is ineffective or unnecessary. This belief increases over time, and could be the result of a non-clinical selective-attention bias.

Cherubini, P., Rumiati, R., Bigoni, M., Tursi, V., & Livi, U. (2003). Long-term decrease in subjective perceived efficacy of immunosuppressive treatment after heart transplantation. THE JOURNAL OF HEART AND LUNG TRANSPLANTATION, 22(12), 1376-1380 [10.1016/S1053-2498(03)00023-8].

Long-term decrease in subjective perceived efficacy of immunosuppressive treatment after heart transplantation

CHERUBINI, PAOLO;
2003

Abstract

Background: Mild, long-term non-compliance with immunosuppressive treatment after organ transplantation is common, and can result in early mortality. One possible source of non-compliance is the belief that the treatment is ineffective or unnecessary. This study investigates patients perception of the efficacy of their immunosuppressive treatment in a sample of heart transplant patients. Methods: A questionnaire was given to 67 heart transplant recipients. The first part of the questionnaire addressed health-related behavior and attitude toward the immunosuppressive medication, using self-report questions. In the second part of the questionnaire, participants evaluated the perceived risk of rejection associated with non-compliant behaviors described in 8 scenarios. Results: The data from the self-report questions showed a mild level of behavioral non-compliance, increasing over time, and a mild level of medication non-compliance. One third of the medication non-compliant patients chose the inefficacy or non-necessity of the treatment as a main cause of non-compliance. The second part of the questionnaire showed that subjective perceived efficacy of the immunosuppressive treatment decreased over time. Conclusions: Medication non-compliance is fostered by many factors. One of these is the belief that the treatment is ineffective or unnecessary. This belief increases over time, and could be the result of a non-clinical selective-attention bias.
Articolo in rivista - Articolo scientifico
immunosuppression, transplanation, perceived efficacy, compliance
English
Cherubini, P., Rumiati, R., Bigoni, M., Tursi, V., & Livi, U. (2003). Long-term decrease in subjective perceived efficacy of immunosuppressive treatment after heart transplantation. THE JOURNAL OF HEART AND LUNG TRANSPLANTATION, 22(12), 1376-1380 [10.1016/S1053-2498(03)00023-8].
Cherubini, P; Rumiati, R; Bigoni, M; Tursi, V; Livi, U
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10281/6718
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